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7/98. medslides.com. 2. Pathogenesis. Disruption of the endocardial layer as a complication of abnormal blood flow associated with underlying cardiac defectBacterium-endothelium interaction with bacterial attachment and invasion of endothelial cells. 7/98. medslides.com. 3. Epidemiology. Underlyin
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1. 7/98 medslides.com 1 Update onInfective Endocarditis Larry Baddour, MD
University of Tennessee
2. 7/98 medslides.com 2 Pathogenesis Disruption of the endocardial layer as a complication of abnormal blood flow associated with underlying cardiac defect
Bacterium-endothelium interaction with bacterial attachment and invasion of endothelial cells
3. 7/98 medslides.com 3 Epidemiology Underlying valvular abnormality predisposing to infective endocarditis
rheumatic fevera common cause in the past
mitral valve prolapsecurrently represents the most common underlying cardiac abnormality
4. 7/98 medslides.com 4 mitral valve prolapse risk for infective ednocarditis is ?5x-8x
mitral regurgitation increases the risk
leaflet redundancy with myxomatous degeneration is a frequent finding
age <20 , female predominateage >20 , male accounts for 60%age >50 , male accounts for 68%
5. 7/98 medslides.com 5 Mitral Valve Prolapse and Infective Endocarditis