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Hepatitis C Last updated May 2013

Hepatitis C Last updated May 2013. Hepatitis C virus (1). Virus first identified in 1989 Routine screening of blood started in 1991 Many people were infected through contaminated blood/blood products prior to this Most new cases in developed countries are in injecting drug users

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Hepatitis C Last updated May 2013

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  1. Hepatitis CLast updated May 2013

  2. Hepatitis C virus (1) • Virus first identified in 1989 • Routine screening of blood started in 1991 • Many people were infected through contaminated blood/blood products prior to this • Most new cases in developed countries are in injecting drug users • Hepatitis C can also be transmitted sexually and from an infected mother to her baby – but these routes are less common • Most cases are initially asymptomatic or mildly symptomatic • 55-85% of those infected develop chronic infection

  3. Hepatitis C virus (2) • Chronic infection can lead to chronic liver disease, cirrhosis, liver failure and liver cancer (usually over 20-30+ years) • >170 million people chronically infected worldwide • No vaccine available • Standard treatment: • Combination therapies using interferon and new antiviral drugs have steadily improved the rate of cure (sustained virological response) in the last decade. • Treatment success rate of up to 80% depending on various factors.

  4. Worldwide prevalence hepatitis C infection (source: WHO)

  5. Number or notifications hepatitis C 2004-2012, by sex and mean age

  6. Epidemiology of hepatitis C in Ireland • Hepatitis C became notifiable in 2004 • 2004-2012: 11,568 cases notified, mean annual number: 1,285 • Crude notification rate in 2012: 24.4/100,000 • Likely to include some cases diagnosed before 2004 and not previously notified, and some duplicates (as full names not always provided) • 65% of cases notified 2004-2012 were male • The median age at notification 2004-2012 was 34 years • Risk factor data collected since early 2007 – data available for 55% of cases notified between 2007 and 2012 • 77% were injecting drug users

  7. Mean annual notification rates per 100,000 for hepatitis C by age and sex, 2004-2012

  8. Mean annual notification rates of hepatitis C per 100,000 population by HSE area, 2004-2012

  9. Most likely risk factor (%) for cases of hepatitis C notified in 2012 (where data available, n=651, 63%)

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