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ASCO Annual Meeting 2013 Poster presentation

ASCO Annual Meeting 2013 Poster presentation. TARGIT-A trial: Updated results for local recurrence and survival for the German centers Presenter: Frederik K. Wenz. 5 years results: 734 patients, 7 centres in Germany Absolute number of events in TARGIT vs. EBRT :

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ASCO Annual Meeting 2013 Poster presentation

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  1. ASCO Annual Meeting 2013 Poster presentation

  2. TARGIT-A trial: Updated results for local recurrence and survival for the German centers Presenter: Frederik K. Wenz • 5 years results: • 734 patients, 7 centres in Germany • Absolute number of events in TARGIT vs. EBRT : • Primary outcome: IBR 4 vs. 1 • Exploratory outcome: All recurrences (breast +axilla+contralateral+distant recurrence) 11 vs. 7 • Secondary outcome: • All deaths 6 vs. 12 • Breast Cancer deaths 3 vs. 5 • Non-Breast Cancer deaths 3 vs. 7 • Message: • The 734 German patients have excellent 5 year outcomes • in both arms of the trial • Survival was better in TARGIT than in EBRT Source: J Clin Oncol 31, 2013 (suppl; abstr 1121)

  3. Intraoperative versus external beam boost for breast cancer: A matched-pair analysis Presenter: Elena Sperk • Matched pair analysis impact on overall survival of IORT boost vs. EBRT boost : • 370 patients with 53 pairs • Medium Follow up: 56 month in IORT vs. 6 month in EBRT • Strong trend towards better overall survival after IORT boost (90.2% vs. 62.3%, p = 0.375) • IBR 1 vs. 1 • Message: • IORT given as a boost seems to have a positive impact on overall survival in breast cancer patients after breast conserving surgery Source: J Clin Oncol 31, 2013 (suppl; abstr 1120)

  4. Intraoperative radiotherapy in early breast cancer: 400 consecutive patients in one institution Presenter: Mariana Steiner • Single center experience since 2006 IORT only vs. WBRT in low risk early breast cancer patients (in patients with high risk tumor characteristics at final pathology, additional local breast therapy) • 400 patients • Medium Follow up: 30 month (43 months in the first 200 patients) • Seven ipsilateral breast failures (1.7%) and one axillary recurrence were observed • Message: • Center concludes that intraoperative radiotherapy using the Intrabeam system is feasible and may offer an alternative to whole breast RT in low risk breast cancer patients • Clinically significant local morbidity rate is low Source: J Clin Oncol 31, 2013 (suppl; abstr 1108)

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