Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection)

1. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) © Clearsky Pharmacy ( www.clearskypharmacy.biz )

2. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Eutrig-HP (Generic Human Chorionic Gonadotrophin Injection) is a hormone that is used to cause ovulation and to treat infertility in women. This medicine is not effective in women with primary ovarian failure. In female infertility it can be used to cause women to ovulate (Ovulation induction). Eutrig-HP is also used along with other fertility medicines, to help produce eggs in medically assisted reproduction programmes (IVF treatment). Human Chorionic Gonadotropin Injections (HCG) is used in men to treat hypogonadism, a condition in which the body doesn't produce enough testosterone. HCG is also used in young boys whose testicles have not descended (dropped) into the scrotum as normally expected during growth. HCG is usually given for this condition in boys who are 4 to 9 years old. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

3. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Active Ingredient The active ingredient present in Eutrig-HP HCG injection is Human Chorionic Gonadotropin. Each vial of HCG injection contains 2000 iu, 5000 iu or 10000 iu of purified Human Chorionic Gonadotropin. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

4. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Chemical Structure The structure of Human Chorionic Gonadotrophin is given below: © Clearsky Pharmacy ( www.clearskypharmacy.biz )

5. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Eutrig-HP Injections (Generic Human Chorionic Gonadotrophin Injections) are manufactured by Samarth Life Sciences Private Limited, India in the strength of2000iu, 5000iu and 10000iu. (Website: https://samarthlife.com/ https://samarthlife.com/) URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

6. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Human Chorionic Gonadotrophin Injections – Brand Names Human Chorionic Gonadotropin Injections are available under different drug brand names such as Pregynl, Eutrig-HP, HUCOG, ZyhCG, Ovidrel, Novarel, Fertigyn, Vitagon, Chorex, Corion and Choragon. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

7. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Uses of Eutrig-HP 2000iu, 5000iu and 10000iu Injections Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) has different uses for females and males. Chorionic gonadotropin injection (Eutrig-HP Injection) is a hormone used as a fertility medicine to develop eggs in women who have not been able to become pregnant because of problems in ovulation. It is also used to help men with low sperm counts produce more sperms and used when testicles have not dropped down in the scrotum which is caused by a pituitary gland problem. In females, chorionic gonadotropin is used to help conception occur. It is usually given in combination with other drugs such as menotropins and urofollitropin. Many women being treated with these drugs usually have already tried clomiphene alone and have not been able to conceive yet. Chorionic gonadotropin is also used in in-vitro fertilization (IVF) programs. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

8. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Uses of Eutrig-HP 2000iu, 5000iu and 10000iu Injections In males, LH and chorionic gonadotropin stimulate the testes to produce male hormones such as testosterone. Testosterone causes the enlargement of the penis and testes and the growth of pubic and underarm hair. It also increases the production of sperm. 1. Prepubertal cryptorchidism not due to anatomical obstruction. In general, HCG is thought to induce testicular descent in situations when descent would have occurred at puberty. HCG thus may help predict whether or not orchiopexy will be needed in the future. Although, in some cases, descent following HCG administration is permanent, in most cases, the response is temporary. Therapy is usually instituted in children between the ages of 4 and 9. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

9. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Uses of Eutrig-HP 2000iu, 5000iu and 10000iu Injection 2. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) is used to treat selected cases of hypogonadotropic hypogonadism (hypogonadism secondary to a pituitary deficiency) in males. 3. Induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure, and who has been appropriately pretreated with human menotropins. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

10. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Eutrig-HP Injections Dosage The dosage of Eutrig-HP Injection Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) is given below: Induction Of Ovulation And Pregnancy In The Anovulatory Infertile Induction Of Ovulation And Pregnancy In The Anovulatory Infertile Woman: Woman: The recommended dosages for Eutrig-HP administration are for induction of ovulation and pregnancy in the anovulatory, infertile woman in whom the cause of anovulation is secondary and not due to primary ovarian failure and who has been appropriately pretreated with human menotropins. 5000 to 10000 USP units one day following the last dose of menotropins. Prepubertal Cryptorchidism Not Due To Anatomical Obstruction: Prepubertal Cryptorchidism Not Due To Anatomical Obstruction: 4,000 USP units, 3 times weekly, for 2 to 3 weeks, or 1,000 USP units, 3 times weekly for 6 to 8 weeks. The HCG dosage schedule may change to some extent, depending upon the age when treatment is given. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

11. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Eutrig-HP Injections Dosage The dosage of Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) is given below: Selected Cases Of Hypogonadotropic Hypogonadism In Males: Selected Cases Of Hypogonadotropic Hypogonadism In Males: 4,000 to 5,000 USP units 3 times weekly for 6 to 8 weeks with a rest of period of 2 to 3 weeks between courses of therapy. Delayed Adolescence: Delayed Adolescence: 4000 to 5000 USP units three times weekly for six to eight weeks with a rest period of two to three weeks between courses of therapy. Dwarfism (pituitary): Dwarfism (pituitary): 1000 to 5000 USP units three times weekly. Hypogonadotropic Eunuchoidism: Hypogonadotropic Eunuchoidism: 4000 to 5000 USP units three times weekly for six to eight weeks with a rest period of two to three weeks between courses of therapy. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

12. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Contraindications Eutrig-HP injections are contraindicated in persons with a hypersensitivity (allergy) to Human Chorionic Gonadotropin or any of the other ingredients of this medicine. This medicine is also containdicated in patients with Precocious puberty, prostatic carcinoma or other androgen-dependent neoplasm. HCG may cause fetal harm when administered to a pregnant woman. Combined HCG/PMS (pregnant mare’s serum) therapy has been noted to induce high incidences of external congenital anomalies in the offspring of mice, in a dose- dependent manner. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

13. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Storage Instructions Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) have to be stored at controlled room temperature i.e. from 20°C to 25°C (68°F to 77°F) with excursions permitted between 15° to 30°C (59° to 86°F). If reconstituted solution in vial is not used immediately, then store refrigerated [2°C to 8°C (36°F to 46°F)] until use and discard after 60 days. Do not shake. Do not freeze. Keep this as well as all other medicines away from children and pets. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

14. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Warnings Gonadotropins, including Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection), should only be used by physicians who are thoroughly familiar with infertility problems and their management. Anaphylaxis has been reported with urinary-derived HCG products. Mild to moderate uncomplicated ovarian enlargement which may be accompanied by abdominal distention and/or abdominal pain may occur in patients treated with FSH and hCG, and generally regresses without treatment within two or three weeks. Careful monitoring of ovarian response can further minimize the risk of overstimulation. OHSS is a medical event distinct from uncomplicated ovarian enlargement. Severe OHSS may progress rapidly (within 24 hours to several days) to become a serious medical event. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

15. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Warnings Severe OHSS is characterized by an apparent dramatic increase in vascular permeability which can result in a rapid accumulation of fluid in the peritoneal cavity, thorax, and potentially, the pericardium. The early warning signs of development of OHSS are severe pelvic pain, nausea, vomiting, and weight gain. As with other hCG products, reports of multiple births have been associated with Eutrig-HP treatment. In ART, the risk of multiple births correlates to the number of embryos transferred. Pulmonary and Vascular Complications: As with other hCG products, a potential for the occurrence of arterial thromboembolism exists. Serious pulmonary conditions (e.g., atelectasis, acute respiratory distress syndrome) have been reported in women treated with gonadotropins. In addition, thromboembolic reactions both in association with, and separate from OHSS have been reported following gonadotropin therapy. © Clearsky Pharmacy ( www.clearskypharmacy.biz )

16. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Warnings Ovarian torsion has been reported after treatment with gonadotropins. Multi-fetal gestation and births have been reported with all gonadotropin therapy including hCG. Advise women of the potential risk of multiple births before starting treatment with gonadotropins including Eutrig-HP Injections. The incidence of congenital malformations after ART may be slightly higher than after spontaneous conceptions. Infertile women undergoing Assisted Reproductive Technologies (ART) have an increased incidence of ectopic pregnancy. Early ultrasound confirmation that a pregnancy is intrauterine is therefore important. The risk of spontaneous abortion (miscarriage) is increased with gonadotropin products. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

17. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Side Effects Human Chorionic Gonadotropin Injection (Eutrig-HP Injection) Side effects include Headache, irritability, restlessness, depression, fatigue, edema, precocious puberty, gynecomastia, pain at the site of injection. Hypersensitivity reactions, both localized and systemic in nature, have been reported. Call your doctor immediately in case you have any of these signs of a blood clot: pain, warmth, redness, numbness, or tingling in your arm or leg; confusion, extreme dizziness, or severe headache. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

18. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Side Effects Inform your doctor immediately in case you are experiencing any signs of an allergic reaction: skin rash, itching or hives, swelling of the face, lips, or tongue. For boys: acne; breast enlargement; enlargement of penis and testes; development of facial or pubic hair; a sudden increase in height. For women on fertility treatments: indigestion; nausea, vomiting; passing small amounts of urine; shortness of breath; stomach area or pelvic pain or bloating; swelling; rapid weight gain. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

19. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Eutrig-HP HCG Injection Overdose Get immediate emergency medical assistance in case you think you have used too much of this medicine. An overdose of Human Chorionic Gonadotropin Injection (Eutrig-HP Injection) is not expected to produce life- threatening symptoms. Symptoms could include blood clots, pain at the site of the injection, numbness, tingling, confusion, dizziness and headaches. Call your doctor right away if you have any signs or symptoms of OHSS: severe pelvic pain, swelling of the hands or legs, stomach pain and swelling, shortness of breath, weight gain, diarrhea, nausea or vomiting, and urinating less than normal. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

20. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Eutrig-HP Injections During Pregnancy Human Chorionic Gonadotropin Injection (Eutrig-HP Injection) is classified by the US FDA as Pregnancy Category X and is contraindicated after conception has occurred. When administered to mice, animal derived formulations of exogenous HCG have induced a high incidence of external congenital anomalies. Defects of forelimbs and central nervous system and alterations in sex ratio have been reported in mice receiving combined gonadotropin and Chorionic Gonadotropin therapy in dosages to induce superovulation. Therefore, pregnancy should be ruled out prior to the administration of Eutrig-HP with each fertility treatment course. In addition to potential effects on the fetus, protocols using HCG inherently increase the risk of multiple gestation and the risks associated with such pregnancies. Do not use this medication if you are pregnant. Inform your doctor immediately if you become pregnant during treatment. URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )

21. Eutrig-HP Injection (Generic Human Chorionic Gonadotrophin Injection) Eutrig-HP Injection Eutrig-HP Injection(Generic Human Chorionic Gonadotrophin Injection) manufactured by Samarth Life Sciences Private Limited, India URL: URL: https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html https://www.clearskypharmacy.biz/eutrig-hp-hcg-injection.html © Clearsky Pharmacy ( www.clearskypharmacy.biz )