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The Association Cortex. The Neocortex. The Association Cortices ( Brodmann’s Areas). s pace ,time, motion, planning, decision making, emotional reactivity, memory, recall, etc. . HOW DO WE KNOW THIS?????. Association Cortices Across Species. Basic Properties of the Association Cortex.
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The Association Cortices (Brodmann’s Areas) space ,time, motion, planning, decision making, emotional reactivity, memory, recall, etc. HOW DO WE KNOW THIS?????
Basic Properties of the Association Cortex • At least 1 primary source of INPUT and OUTPUT from other cortical or sub-cortical brain areas
Thalamus: Gateway of Neural Information • If you recall…. • vision (hearing) made possible through the travel of neuronal information from the retina (cochlea) to the occipital (temporal) cortex via lateral (medial) geniculate leaflet • Pulvinar Nucleus: Parietal Assocation Cortex • Lateral Posterior: Temporal Association Cortex • Medial Dorsal: Frontal Association Cortex
Basic Properties of the Association Cortex • Connections to and from the association cortex on vertical (columnar) and horizontal (lateral) axes
Spatial Representation of Vertical Inputs to Association Cortex
Basic Properties of Association Cortex • Cells with similar functions aligned radially (for the most part) • Any functionally similar cell groups that are aligned horizontally are done so through interneurons
Basic Properties of Association Cortex • Contralateral information travels via the corpus callosum or anterior commissure Disruption: Dyslexia
Damage to Association Cortices • Frontal • Parietal • Temporal • Lesions and Ischemic Damage to these cortices result in neglect or agnosias • Difference: Neglect= “Don’t See It” vs. Agnosia= “See it, but Don’t Know It”
Frontal Damage • Historical case study of Phineas Gage (1800s) and his new polarizing personality
Deficits of Attention, Decision Making, and Gratification • Anterior cingulate cortex • Neuropathology of ADD, for example • Patients perform poorly on Stroop Test
Deficits of Attention, Decision Making, and Gratification • Orbitofrontal Cortex • Neuropathology of OCD and antisocial personality disorder, for example
Deficits in Planning • Dorsolateral Prefrontal • Delayed Response Task is a measure of planning deficiency
Contralateral Neglect Syndrome (Visuospatial Deficit of “Not Seeing”) Parietal Damage
Primarily due to damage of right parietal association cortex
Agnosias (“Seeing, but Not Knowing”) • Great leisurely, science reading on these syndromes by Oliver Sacks -The Man Who Mistook His Wife for a Hat - The Island of the Colorblind • Prosopagnosia • Appreceptive • Akinestopsia • Achromatopisa (*hereditary) Temporal Damage
The inability to differentiate and remember faces due to damage of the inferior temporal lobe Prosopagnosia
An inability to differentiate and remember objects due to damage of the posterior right hemisphere AppreceptiveAgnosia
An inability to differentiate motion due to damage of the medial temporal cortex (“A Life In Still Frames”) Akinestopsia
An inability to differentiate between colors (“A Life in Black and White”) due to a hereditary deficit resulting in improper brain development Achromatopsia
A brain pacemaker • Novel treatment strategy for Parkinson’s and associative disorders like OCD, ADD, and depression Deep Brain Stimulation