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Clinical case - objective. 25 y . caucasian ♂ bodybuilder ( 188 cm , 92 kg ) 2006.04. starts AS according the scheme : 1 pill (5 mg) Nerobol (Methandienone) 3 time/day I week 4 time/day II week 5 time/day II I week
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Clinical case - objective • 25 y. caucasian ♂bodybuilder (188 cm, 92 kg) • 2006.04. starts AS according the scheme: • 1 pill (5 mg) Nerobol (Methandienone) 3 time/day I week • 4 time/day II week • 5 time/day III week • 6time/day IV week – and 1 amp Deca Durabolin (Nandrolone) each 5 daysi/m • Total per 2 monts 240 pills (1200 mg) Nerobol and 8 amp (400-800 mg ?) Deca Durabolin • Patient’s friend with the similar constitution used the same scheme – no symptoms
Clinical case – first symptoms • No any symptoms for 2 months • After 2 months: • headache • loss of appetite • insomnia • disphagia • Loss of weight (15 kg during 5 weeks) • Increasing itch and jaundice
Clinical case – outpatient treatment • Risk factor – physicians in family : • Infectionist – no infections • Reumatologist – no autoimmune disease • Medications: • loratadinum 10 mg p/o • ornitinum aspartate 9 g p/o • BZD
Clinical case – outpatient examination • Abdominal echoscopy - normal • TB: ~130→376 • DB: ? →299 • SGPT/ALT: 90 • ALP: 215
Clinical case – hospitalization • Arrival 06.16: • Significant jaundice • Ichterus • Scratches and excoriations everywhere • Encephalopaty
Clinical case – inpatient examination • TB 564→436→465→449→564→445 • DB 460 →368→363→394→491→381 • SGPT/ALT 75 →66→91→64→83→82 • SGOT/ASAT286→106→67→54→59→62 • ALP284 →228→234→193→232→184 • CRPnot found • CBC normal levels • Total Ch 4,4 → 4,01 • HDL Ch 0,35→ 0,08 (normal level >1) • LDL Ch 3,74 → 3,94 • TG 3,49 → 3,82
Clinical case – instrumental investigations • X-ray examination of Thorax – normal • Abdominal echoscopy - normal
Clinical case – echocardiography • Decreased LVejection fraction 40% (normal value >55%), hypokinesis in LVinferior and inferolateral wall andinterventriculum septum bottom segments. Damaged diastolic function of LV
Clinical case – treatment • Prednisolone 1mg/kg • Ornitinum aspartati 18 g p/o • Sylimarins • Neuroleptics • BZD • HBO • Hepatic Diet