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Engineering Tissues

Engineering Tissues. Esther Johnson Physics, Del Rio High School Dr. Alvin Yeh, Associate Professor of Biomedical Engineering Dr. Arne Lekven, Associate Professor of Biology. Nonlinear Optical Microscopy. Setup. Noninvasive High resolution 3D Images Two Photon Fluorescence

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Engineering Tissues

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  1. Engineering Tissues

    Esther Johnson Physics, Del Rio High School Dr. Alvin Yeh, Associate Professor of Biomedical Engineering Dr. Arne Lekven, Associate Professor of Biology
  2. Nonlinear Optical Microscopy Setup Noninvasive High resolution 3D Images Two Photon Fluorescence Second Harmonic Generation (SHG)
  3. Zebrafish Embryos are large, robust and transparent Easily observed Embryonic development occurs rapidly Embryos are easily manipulated
  4. Visualizing Development
  5. Engineered Tissue 1.2:1.2 1.2:1.1 1.0:1.0 1.1:1.0 1.1:1.1 Various stretch ratio Yuqiang Bai - Biomechanics Macroscopic Properties of Engineered Tissue Microscopic Properties of Extracellular Matrix Photos courtesy of Yuqiang Bai
  6. Imaging Biaxial Mechanical Testing Photos courtesy of Yuqiang Bai
  7. Relevance Connecting molecular and cellular biology Biomechanics Engineered Tissues Stem cell replacement therapy Cancer research Various other biomedical arenas
  8. Classroom Project TAKS Science Objective 5 Physics TEKS c.3.E, F c.6.B,E
  9. Correlation Research: focus on biomechanics Correlation Elasticity Hooke’s law Test the biomechanical properties of “engineered skin tissue” Photo courtesy of http://hyperphysics.phy-astr.gsu.edu/hbase/permot2.html
  10. Hook: Nitinol Spring Memory metal spring.wmv
  11. Day 1 Hook Activity: Demonstration of Nitinol Spring vs. Regular Spring Ask students why there was a difference Notes on Elasticity and Hooke’s Law Homework (research assignment) Students must go home and research Nitinol springs
  12. Hooke’s Law Elasticity: the property of a substance that enables it to change its length, volume, or shape in direct response to a force effecting such a change and to recover its original form upon the removal of the force (dictionary.com) Hooke’s Law or Elasticity F = -kx F = restoring force exerted by the spring k = spring constant x = displacement of the spring end from its equilibrium position
  13. Day 2 http://phet.colorado.edu/sims/mass-spring-lab/mass-spring-lab_en.html Hooke’s Law computer simulation Homework: Hooke’s Law practice problems
  14. Day 3 Photo courtesy of JL Stanbrough http://www.batesville.k12.in.us/physics/phynet/mechanics/newton3/Labs/SpringScale.html Photo courtesy of Wikipedia Hooke’s Law Lab PowerPoint on my summer research experience
  15. Garry Turner – World’s Stretchiest Skin Stretchiest skin - Guinness World Record2.wmv
  16. Day 4 Engineering Challenge: design a mechanism to test the stretch vs. strain on skin-like materials compare the graphs from engineering challenge with graphs from the Hooke’s Law lab Background: Human Skin Must be elastic If not, it would tear Photo courtesy of exorgroupinc.
  17. The Problem Human skin is considered “viscoelastic” meaning it demonstrates both viscous and elastic properties while it is deformed Graph courtesy of http://www.engin.umich.edu/class/bme456/ligten/ligten.htm Can synthetic skin handle the same kinds of stressors as its biological counterparts?
  18. Procedure Students must design a mechanism to compare the various “skins” to identify which most closely resembles human skin Photos courtesy of http://www.purdue.edu/uns/html4ever/0002.Badylak.SIS.html and http://childrenshospital.org/newsroom/Site1339/mainpageS1339P223.html
  19. Parameters The stress/pull on the fabric must be equally distributed over a cross-section Material must be immobilized on the other side Material cannot be torn or the test has failed Students must decide which material presents a stress-strain graph which most closely resembles human skin’s stress-strain graph.
  20. Materials Various material squares (wool, spandex, cotton, rubber, leather, etc) Ruler Hanging Mass Set Wood blocks Pulley apparatus Cardboard Masking tape Wire hangers Paper clips
  21. Day 5 Post-Test (identical to pretest) Closure/ Discussion
  22. Conclusion Students will Be able to manipulate the Hooke’s Law equation. Analyze and verify Hooke’s Law. Explore the field of Biomedical Engineering Identify practical applications of physics in engineering Design a Biomechanical testing device Evaluate and rank the biomechanical properties of various materials
  23. Acknowledgements Yuqiang Bai Kirsten Brink
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