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Modeling and Verification of the Progression of HC

Modeling and Verification of the Progression of HC. Sukhi Basati LPPD seminar 4/15/09. Overview. Update on Del Bigio data simulation Previous work – ADINA modeling and simulation with solid models and FSI New results include pulsatile pressure deformation of brain tissue.

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Modeling and Verification of the Progression of HC

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  1. Modeling and Verification of the Progression of HC Sukhi Basati LPPD seminar 4/15/09 1

  2. Overview • Update on Del Bigio data simulation • Previous work – ADINA modeling and simulation with solid models and FSI • New results include pulsatile pressure deformation of brain tissue. • Volume Sensor update • Animal protocol issues 2

  3. Why research with animal data when we have human patient data? Voxel size =1.37 mm Simulate with pre_HC or 1 day? 3

  4. How could we benefit with animal data of HC? • Ideas: • First deform pre_HC ventricles in a way that mimics hydrocephalic rat. • (Apply different pressures with time functions to deform irregularly?) • Plot strain, stress or pressure in different regions. • (2d first then 3d) • (Show equations that ADINA solves to get strain, stress, or pressure) • Show differences between material properties. • 2 Methods  Linear elastic solid model or a Poroelastic model with fluid and solid elements • Can we provide conclusive reasons for behavioral defects in hydrocephalic patients? 4

  5. Method A • 2d Circle • Linear Elastic • Solid only 5

  6. Method A 2d Circle Linear Elastic Solid 6

  7. Method B • 2d Circle • Poroelastic • Fluid + Solid 7

  8. 2d Circle • Poroelastic • Fluid + Solid 8

  9. 3d Circle • Linear Elastic Solid • Comparison of statics solution and dynamics implicit • mesh distortion? • Pressure increase from 0 to 50 kPa • Young Modulus = 1000 9

  10. Statics Solution Dynamics Implicit Solution 10

  11. 2d PreHC Rat axial Poroelastic solid with FSI. 11

  12. 2d PreHC Rat axial Poroelastic solid with FSI. 12

  13. 2d PreHC Rat sagittal Poroelastic solid with FSI. 13

  14. 2d PreHC Rat sagittal Linear elastic solid 14

  15. 2d PreHC Rat sagittal Poroelastic solid with FSI. 15

  16. 3d PreHC Rat 1 day post HC ventricles 16

  17. 3d PreHC Rat 1 day post HC ventricles 17

  18. Pulsatile Ventricle Deformation 18

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