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Alternatives to Bu 3 SnH in Radical Cyclisations :

New Trends in Applied Chemistry, Ovidius University of Constanta, 2012 . Alternatives to Bu 3 SnH in Radical Cyclisations : Copper Mediated 4-Exo and 5-Endo Radical Polar- Crossover Reactions. Dr. Andrew Clark Associate Professor of Synthetic Chemistry Director Of Undergraduate Studies

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Alternatives to Bu 3 SnH in Radical Cyclisations :

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  1. New Trends in Applied Chemistry, Ovidius University of Constanta, 2012 Alternatives to Bu3SnH in Radical Cyclisations: Copper Mediated 4-Exo and 5-Endo Radical Polar-Crossover Reactions Dr. Andrew Clark Associate Professor of Synthetic Chemistry Director Of Undergraduate Studies University of Warwick +44 24 76523242 a.j.clark@warwick.ac.uk

  2. Classical Radical Cyclisation • Stoichiometric • Reductive Cyclisation • Toxic Reagents • Purification Issues • Relatively expensive • (10g, £25)

  3. Atom Transfer Radical Cyclisation

  4. A. J. Clark, J. V. Geden, and S. Thom. J. Org. Chem., 2006, 71, 1471

  5. A. J. Clark, J. V. Geden, S. Thom, and P. Wilson, J. Org. Chem., 2007, 72, 5923

  6. 5-Endo Cyclisations Radical-polar crossover reaction

  7. Unprecedented radical-polar-carbene triple crossover reaction

  8. Improving catalysis

  9. Addition of AIBN A. J. Clark, P. Wilson. Tetrahedron Letts., 2008, 49, 4848

  10. Applications

  11. Other reducing agents

  12. Acknowledgements PhD students Gary Battle John McDonagh Joanna Geden Paul Wilson Post Doctoral Alana Collis Funding Aventis Lilly Research Centre AstraZeneca Engineering and Physical Sciences Research Council EPSRC New 700 MHz NMR New teaching lab, October 2012! New Materials and Analytical extension £24M, 5 storeys, 4656 sqm. opened November 2011 New synthetic lab Opened Nov 2010 by Prof. Grubbs

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