Chapter 9 The Muscular System

1. Chapter 9The Muscular System

2. Skeletal Muscle Structure • Tendon – • Fascia – outermost covering; covers entire muscle & continuous w/tendon; separates muscle from adjacent muscles • Aponeuroses-

3. Skeletal Muscle Structure Coverings: • Epimysium – covers entire muscle (under fascia) • Perimysium – • Endomysium – covers each fiber (cell) • Sarcolemma –

4. Skeletal Muscle Structure Skeletal Muscle Structure – Cont. • Sarcoplasmic reticulum (SR) channels for transport • Myofibrils – threads that compose muscle fibers; contain protein filaments: 1. actin – 2. myosin –

5. Skeletal Muscle Structure

6. Muscle Fiber(muscle cell) • Cisternae of SR – enlarged portions • Transverse tubules (T-tubules) – important in muscle contraction • Sarcoplasm –

7. Breakdown of Skeletal Muscle

8. Parts of a Sarcomere (functional unit of a muscle)

9. Parts of a Sarcomere • Z lines – end points • M line – • I band – on either side of Z line; actin filaments only • H zone – on either side of M line; myosin filaments only • A band –

10. Parts of a Sarcomere

11. 4 Proteins in Muscle Cells:

13. Troponin & Tropomyosin • 4 proteins are found in muscle cells: actin, myosin, troponin & tropomyosin • troponin – appear as globules; provide a binding site for Ca+² • tropomyosin–

14. Sliding Filament Theory (How Muscles Contract) • Muscle fiber stimulated by release of ACh from synaptic vesicles of neuron • Transverse tubules (T-tubules) carry impulse deep into muscle fibers • Ca²+ bind to troponin, tropomyosin moves, exposing binding sites on actin filaments

15. Cross Bridge Animation • cross bridge animation

16. Sliding Filament Theory (How Muscles Contract ) • Linkages form b/t actin & myosin • Actin filaments move inward, shortening the sarcomere • The enzyme cholinesterase (or AChesterase) decomposes ACh

17. Sliding Filament Theory • Relaxed muscle – binding sites on actin are covered by tropomyosin

18. Sliding Filament Theory • Ca²+ binds to troponin • Tropomyosin slides out of the way • Myosin binds to actin & pulls inward • Sarcomeres shorten & muscle contracts

19. Sliding Filament Animation • sliding filament animation

20. Sliding Filament Theory

21. Neuromuscular Junction – junction b/t motor neuron & muscle • Motor neuron • Motor end plate – end of muscle fiber; many nuclei & mitochon- dria located here

22. Neuromuscular Junction • Neurotransmitters (ntm) chemicals that help carry impulses • Motor unit – • Synaptic vesicles – store neurotransmitter; most common – acetylcholine (ACh)

24. Electron Micrograph Neuromuscular Junction

25. Neuromuscular Junction Animation • Neuromuscular Junction Animation

26. Energy for Muscle Contraction • ATP (adenosine triphosphate) • When ATP is converted to ADP(adenosine diphosphate) by losing the last phosphate, energy is released.

27. Energy for Muscle Contraction • Cells depend on cellular respiration of glucose to synthesize ATP • An additional source is creatine phosphate

28. Energy for Muscle Contraction • Creatine phosphate stores excess energy • Anaerobic respiration (in the absence of O2) provides few ATP’s, while aerobicresp. (in the presence of O2) provides many ATP’s

29. Creatine Phosphate High amts. of ATP - ATP is used to Low amts. of ATP – CP is used synthesize CP, which stores energy to resynthesize ATP. for later use.

30. Importance of Myoglobin • l.a. carried by blood to liver; liver can convert l.a. to glucose, but requires ATP (ATP being used for muscle contraction) • myoglobin –

31. Aerobic vs. Anaerobic Respiration

32. Aerobic vs. Anaerobic Respiration Carried by blood to liver; liver can convert l.a. to glucose, but requires ATP (ATP being used for muscle contraction) Imp. b/c blood supply during muscle contr. may decrease As l.a. accumulates, O2 debt occurs

33. Oxygen Debt • Strenuous exercise leads to O2 deficiency & lactic acid buildup • ATP provides energy for muscle contraction • Amt. of O2 needed to convert accumulated l.a. to glucose & restore ATP levels = • L.A. accumulation leads to muscle fatigue b/c pH of muscle cell is lowered & muscle cannot contract

34. Muscle Cramp • Muscle cramp – • Rigor mortis – takes up to 72 hrs. to occur; sarcolemma becomes more permeable to Ca+² & ATP levels insufficient

35. Myogram Pattern or graph of a muscle contraction A single contraction is called a 3 parts: Latent (lag) phase – brief pd. of delay b/t when the stimulus is applied & actual contraction occurs Contraction Relaxation –

36. Patterns of Contraction • a) MuscleTwitch – • b) Staircase Effect many stimuli closely spaced w/complete relaxation in b/t; each contraction generate incr. force

37. Patterns of Contraction • c) Summation – when the 2nd stimulus occurs during the relaxation pd. of 1st contr.; the 2nd contr. generates more force • d) Tetany –

38. Muscle Facts • If a muscle is stimulated twice in quick succession, it may not respond the 2nd time – called refractory period • Threshold – • All-or-none – increasing the strength of the stimulation does NOT incr. the degree of contraction (a muscle contracts completely or not at all)

39. More Facts • Incr. stimulation from motor neurons causes a greater # of motor units to contract & vice versa • Called recruitment of motor units • Incr. the rate of stimulation also incr. the degree of contraction • Muscle tone –

40. Hypertrophy vs Atrophy • Hypertrophy- with intense exercise where muscle exerts more than 75% of its max tension there is an increase in actin and myosin fibers and increase muscle fiber diameter. • Inc diameter= • Atrophy-

41. Origin & Insertion • Origin – end of muscle that attaches to stationary bone • Insertion – • During contr., insertion is pulled toward origin

42. Muscle Functions in Groups Prime mover – responsible for most of the movement (ex.- biceps) Synergist – aids the prime mover Antagonist –

43. Structural Differences of 3 Types of Muscle

45. Functional Differences of 3 Types of Muscle

46. Functional Differences - Continued

47. Fast vs Slow Twitch Fibers • Fast vs Slow Twitch Video

48. Fast Twitch vs. Slow Twitch Muscle