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LEAD-6

LEAD-6. Mean change in HbA 1c : -1.12% with liraglutide vs. -0.79% with exenatide (p < 0.0001) Proportion of patients with HbA 1c <7.0%: 54% vs. 43% (p = 0.0015), respectively Weight loss: -3.24 kg vs. -2.87 kg (p = NS), respectively.

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LEAD-6

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  1. LEAD-6 Mean change in HbA1c: -1.12% with liraglutide vs. -0.79% with exenatide (p < 0.0001) Proportion of patients with HbA1c <7.0%: 54% vs. 43% (p = 0.0015), respectively Weight loss: -3.24 kg vs. -2.87 kg (p = NS), respectively Trial design: Patients with type 2 diabetes on maximal doses of metformin, sulfonylurea, or both were randomized to liraglutide 1.8 mg daily (n = 233) vs. exenatide 10 µg twice daily (n = 231) for 26 weeks. Results p < 0.0001 % Conclusions -0.79 • In type 2 diabetes patients, use of liraglutide for 26 weeks was associated with improved glycemic control compared with exenatide • Liraglutide resulted in a greater reduction in mean HbA1c, and a greater proportion of patients who achieved target HbA1c levels -1.12 Mean change in HbA1c Liraglutide Exenatide Buse JB, et al. Lancet 2009;June 8:[Epub ahead of print]

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