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Growth factors

Growth factors. nutrients. translation. Ad VA RNAs. PKR. p70S6K. Ad E4-ORF4. PIP3. eIF-4E. EIF2 a. PTEN. PDK1. RHEB. mTOR. 4E-BP1. PERK. TSC1/2. PI3K. ER stress. Ca 2+. AMPK. Cyt c. Ad E4-ORF1. Apoptosis/cell death. AKT (PKB). Ras. Caspase cascade. Raf. GSK3. Bax/Bak.

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Growth factors

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  1. Growth factors nutrients translation Ad VA RNAs PKR p70S6K Ad E4-ORF4 PIP3 eIF-4E EIF2a PTEN PDK1 RHEB mTOR 4E-BP1 PERK TSC1/2 PI3K ER stress Ca2+ AMPK Cyt c Ad E4-ORF1 Apoptosis/cell death AKT (PKB) Ras Caspase cascade Raf GSK3 Bax/Bak ERK Bad p27 Cyclin D1 ETS CDK4/6 Ad E1B-19K p15 p27 p21 Bid TGFb BclXL/BCL2 CDK4/6 Ad E1A FOXO Rb/p107/p130 Caspase 8 CDK2 p21 Ad E4 ORF6/7 Mdm2 Ad E4-ORF3 E2F FADD PML Fas ARF Bax Puma Noxa CHK1/2 p53 Ad RIDab Viral DNA AdE1B-55K Ad E4-ORF6 Ad E1A ATM/ATR HDAC Ad E1B-55K Ad E4-ORF6 Ad E4-ORF3 p300 Mre11/Rad50/Nbs1 FOXO transcription TRADD NF-KB TNFa TRAF2 DNA replication P IKB IKB NF-KB

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