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Applications of Synthetic Biology

July 8, 2010. 2. Practical Definition of Synthetic Biology. ?making biology easier to engineer" -- Synthetic Biology Engineering Research Center (SynBERC)Applying engineering principles to biological systemsDesignModelingCharacterization. Key enabling technology:DNA synthesis. July 8, 2010. 3.

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Applications of Synthetic Biology

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    1. Applications of Synthetic Biology Kristala L. J. Prather Department of Chemical Engineering, Massachusetts Institute of Technology NSF Synthetic Biology Engineering Research Center (SynBERC) Cambridge, MA, USA Presidential Commission for the Study of Bioethical Issues July 8, 2010

    2. July 8, 2010 2 Practical Definition of Synthetic Biology “making biology easier to engineer” -- Synthetic Biology Engineering Research Center (SynBERC) Applying engineering principles to biological systems Design Modeling Characterization

    3. July 8, 2010 3 Engineering Biology Biological workspace Microbes Mammalian cells Plants .... Broader applications Therapeutics (Pharmaceuticals, Biologics) Energy (esp. Fuels) Chemicals Agriculture ….

    4. July 8, 2010 4 Achievements in Synthetic Biology Therapeutics

    5. July 8, 2010 5 Achievements in Synthetic Biology Therapeutics

    6. July 8, 2010 6 Achievements in Synthetic Biology Fuels

    7. July 8, 2010 7 Achievements in Synthetic Biology Fuels

    8. July 8, 2010 8 Achievements in Synthetic Biology Energy - Solar

    9. July 8, 2010 9 Achievements in Synthetic Biology Chemicals

    10. July 8, 2010 10 Achievements in Synthetic Biology Biological “Computing”, Programmability

    11. July 8, 2010 11 Achievements in Synthetic Biology And extending the principles of design and construction to whole organisms

    12. July 8, 2010 12 Challenges in Synthetic Biology Biology is complex, and often context-dependent. Synthesis capabilities far exceed design capabilities. We know how to build, but not yet what to build. Potential benefits are enormous. Food, Energy, Medicine Potential risks are real. Technological improvements are not limited to beneficial use.

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