1 / 38

Understanding Schistosomiasis and Fascioliasis: Pathology, Diagnosis, and Treatment

Explore the cellular reactions and pathology of Schistosoma mansoni and Schistosoma haematobium in liver and bladder, as well as the clinical manifestations and treatment options for both urinary and intestinal schistosomiasis. Learn about the life cycle of Fasciola hepatica, its transmission, diagnosis methods, and the drug of choice - Triclabendazole.

cromero
Download Presentation

Understanding Schistosomiasis and Fascioliasis: Pathology, Diagnosis, and Treatment

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The Trematodes

  2. Developing schistosome in liver

  3. Eggs of Schistosoma mansoni

  4. Eggs of Schistosoma mansoni in the liver

  5. Cellular reaction around eggs of Schistosoma mansoni

  6. Egg of S. haematobium Schistosomaiasis granuloma

  7. Schistosomaiasis granuloma

  8. Schistosoma haematobium Causes urinary schistosomiasis PREPATENT PERIOD 10-12 wks EGG DEPOSITION AND EXTRUSION: painless haematuria Inflammation of bladder and burning micturition TISSUE PROLIFERATION AND REPAIR: Fibrosis , papillomata in the bladder and lower ureter leading to obstructive uropathy. Periportal fibrosis Lung and CNS involvement Schistosoma mansoni Causes intestinal schistosomiasis PREPATENT PERIOD 5-7 wks EGG DEPOSITION AND EXTRUSION: dysentery (blood and mucus in stools), hepatomegaly splenomegaly TISSUE PROLIFERATION AND REPAIR:Fibrosis , Papillomata in intestine, Pperiportal fibrosis,hematemesis Lung and CNS involvement. Pathology of Schistosomiasis

  9. Schistosome dermatitis, or "swimmers itch” occurs when skin is penetrated by a free-swimming, fork-tailed infective cercaria. Source: WikiMedia.

  10. Bladder lesions in urinary schistosomiasis

  11. Hepatosplenomegaly in chronic schistosomiasis

  12. Portal hypertension in chronic schistosomiasis

  13. Portal–systemic anastomoses

  14. Schistosoma haematobium Parasitological: Examination of urine Immunological Serological tests Indirect: Radiological Cystoscopy Schistosoma mansoni Parasitological Examination of stools Immunological Serological tests Indirect: Radiological endoscopy Diagnosis of Schistosomiasis

  15. Egg of S. haematobium Egg of S. japonicum Egg of S. haematobium

  16. Egg of S. mansoni

  17. Drug of choice for schistosomiasis isPraziquantel

  18. Life-cycle of Fasciola hepatica

  19. Snail intermediate host of : Fasciola hepatica

  20. Watercress , one means of transmission of fascioliasis

  21. Fasciola hepatica Fasciola hepatica

  22. Fasciola hepatica • Pathology and clinical picture : • True infection causes mainly biliary obstruction and liver damage . • False infection is when eggs are eaten in infected animal liver and passed in stools. • Diagnosis: eggs in stools or duodenal aspirate. • Treatment: Triclabendazole.

  23. Fasciola hepatica adult Fasciola hepatica in bile duct

  24. Egg of Fasciola hepatica

  25. Triclabendazole is the drug of choice to treat fascioliasis and is on the WHO list of essential medicines. The correct dosage is calculated based on the person’s weight (10 mg/kg) and the tablets are given at one time.

  26. Sheep liver infected with Fasciola hepatica

  27. Fasciola hepatica: spurious infection

  28. Fasciola hepatica: spurious infection (eggs in stools)

More Related