1 / 16

Behaviour

Diseases. Environment . Infectious diseases. Behaviour. Genetics. Drug Discovery and BioMedical research in the 21 st century? The third revolution . The first revolution: The era of incidental discoveries 1930s-1960s. Penicillin. The second revolution 1970s-2000s

dacey
Download Presentation

Behaviour

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Diseases Environment Infectious diseases Behaviour Genetics

  2. Drug Discovery and BioMedical research in the 21st century? The third revolution

  3. The first revolution: The era of incidental discoveries 1930s-1960s

  4. Penicillin

  5. The second revolution 1970s-2000s High throughput – brute force screening of large libraries of chemical compounds

  6. Statins Akira Endo

  7. Future medicine- Targeted and Personally “fitted” medicine – Personalized Medicine

  8. Medicine of the 21st Century – The 4P’s Medicine (Leroy Hood) Personalized, Predictive, Preventive, and Participatory Medicine Stem cell-based therapies

  9. Future medicine- Targeted and Personally “fitted” and medicine - Personalized Medicine Breast Cancer – Estrogen Receptor Negative and Positive (predicts sensitivity to Tamoxifen)

  10. The Human Genome Size of the entire Human Genome = 3 Billion Bases

  11. What are the obstacles – they appear to be broader and more complicated than just target identification and validation : • Many diseases (metabolic, psychiatric) are multigenic, and the causative connection between the genes products is not clear • 2. Malignancies are characterized by genomic instability and therefore targets are not stable • 3. Human experimentation is complicated (HRT, stents) • 4. Lack of faithful animal models (neurodegeneration, cancer, metabolic diseases) • Cost of developing new drugs - legal liability (Vioxx/Celebrex), markets (new antibiotics), and patents protection (AIDS - South Africa, India) • End of blockbuster drugs era • 7. Bioethical problems of availability of genetic information

More Related