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Mediterranean School of Oncology

Mediterranean School of Oncology. CINBO Consorzio Interuniversitario Nazionale pre la Bioncologia. BINOMIO MOLECOLARE DIAGNOSTICO E TERAPEUTICO: STATO DELL’ARTE E PROSPETTIVE FUTURE. Nuovi bersagli molecolari e loro applicazioni. Individuazione del bersaglio molecolare Gene profiling.

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Mediterranean School of Oncology

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  1. Mediterranean School of Oncology CINBO Consorzio Interuniversitario Nazionale pre la Bioncologia

  2. BINOMIO MOLECOLARE DIAGNOSTICO E TERAPEUTICO: STATO DELL’ARTE E PROSPETTIVE FUTURE Nuovi bersagli molecolari e loro applicazioni Individuazione del bersaglio molecolare • Gene profiling Bersagli molecolari selezionati: consolidati e nuovi • Apoptosi, TRAIL • Fattori di crescita e loro recettori • Proteasoma • Angiogenesi • Regolazione trascrizionale ed epigenetica come bersaglio terapeutico • Micro RNA: the New World • Applicazioni nei tumori solidi e ematologici • Mammella, Tratto GE, Polmone, Apparato Genitale Femminile, Mieloma, APL

  3. Gene Profiling in the Prognostic Evaluation

  4. Lung Breast Ovary

  5. Receptor-type TK signalling Survival Growth Angiogenesis

  6. Block of VEGF or EGFR in Cancer Treatment

  7. Mutations of EGFR are pathogenetic and treatment sensitizing Science June 2004 Science Aug 2004

  8. Alterations of apoptotic pathways in human cancer From Kaufmann & Vaux, Oncogene, 22: 7414, 2003

  9. Cytoplasmic nuclear transition NF-kB: a fundamental role in cancer pathogenesis, a target in cancer therapy A proteasome based regulation

  10. The proteasome as a target of cancer therapy Proteasome inhibitors: Velcade (bortezomib)

  11. Retinoic acid induces differentiation of APL blasts Expressing PML/RARa 10-6 M (or RA 10-9 M)

  12. Landmarks in cancer epigenetics Clinical trials with demethylating and deacetylase inhibiting agents Altered histone methylation in human cancer Altered gene methylation in cancer Chromatin remodelling by deacetylation in human cancer 1998 2002 2003 1983 1989 Hypermethylation of a tumor suppressor gene in cancer

  13. Many HDAC Inhibitors are entering clinical trials

  14. Chromatin remodelling in gene regulation

  15. Micro-RNA: the future?

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