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DNA. The code of life. DNA is described as a twisted ladder DNA is made up of Nitrogen Bases (rungs of the ladder) Phosphate and Sugar “backbone” Nitrogen Bases Nitrogen is an element of life! (Remember CHON?) There are 4 Bases: Adenine (A) Thymine (T) Cytosine (C) Guanine (G).
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DNA The code of life
DNA is described as a twisted ladder • DNA is made up of • Nitrogen Bases (rungs of the ladder) • Phosphate and Sugar “backbone” • Nitrogen Bases • Nitrogen is an element of life! (Remember CHON?) • There are 4 Bases: • Adenine (A) • Thymine (T) • Cytosine (C) • Guanine (G) 1. Structure of DNA
Like a puzzle, only certain nitrogen bases pair with one another. • Adenine pairs with Thymine • Cytosine pairs with Guanine • A-T and C-G 2. Base Pairing
The first person to isolate DNA • Worked with White Blood Cells • White blood cells are cells that fight invaders in your body Some DNA History – Friedrich Meischer
Isolated DNA from different organisms • Measured the amounts of the four bases (adenine, thymine, cytosine, and guanine) • He found that the amount of adenine = thymine and cytosine = guanine! • Therefore, A pairs with T and C pairs with G! Some DNA History - Chargaff
British BioPhysicist • Made great contributions to the understanding of DNA • Her X-Ray diffraction images of DNA led to the discovery of the DNA double helix • Died at 37 from complications of ovarian cancer Some DNA History – Rosalind Franklin
Franklin’s DNA photographs helped Watson and Crick figure out the structure of DNA in 1953 • Were awarded the nobel prize in 1962 DNA History – Watson and Crick
To replicate means “to make a copy” • During interphase, the DNA is copied to prepare itself for cell division • The copy made is the exact same DNA as the parent DNA. 3. DNA Replication
The DNA molecule “unzips” between the paired bases • New bases that float around in the nucleus are added to the old strand • Each new DNA molecule exactly matches the order in the original! What do you think would happen if there were mistakes made during DNA replication? (for example, wrong base pairs were added?) DNA Replication – The Process
Replication to Protein http://www.youtube.com/watch?v=1fiJupfbSpg
Discovery • http://www.youtube.com/watch?v=sf0YXnAFBs8 • Structure • http://www.youtube.com/watch?v=qy8dk5iS1f0 DNA Structure