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Presentation objectives. Provide an overview of Cochrane Collaboration Demonstrate The Cochrane Library Invite participation. Cochrane Collaboration.
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Presentation objectives • Provide an overview of Cochrane Collaboration • Demonstrate The Cochrane Library • Invite participation
Cochrane Collaboration • An international organisation that aims to help people make well-informed decisions about healthcare by preparing, maintaining and promoting the accessibility of systematic reviews of the effects of health care interventions.
Archie Cochrane “It is surely a great criticism of our profession that we have not organised a critical summary, by specialty or subspecialty, adapted periodically, of all relevant randomised controlled trials.”
Principles • Collaboration • Building on the enthusiasm of individuals • Avoiding duplication • Minimising bias
Principles • Keeping up to date • Striving for relevance • Promoting access • Ensuring quality • Continuity
Cochrane Collaboration goals • To ensure high quality, up-to-date systematic reviews are available across a broad range of health care topics • To promote access to Cochrane reviews
Cochrane Collaboration goals • To develop an efficient, transparent organisational structure and management system for the Cochrane Collaboration • To achieve sustainability of the Cochrane Collaboration
Systematic review Systematic review Systematic review • Structured process involving several steps: • Well formulated question • Comprehensive data search • Unbiased selection and abstraction process • Critical appraisal of data • Synthesis of data
Cochrane Collaboration Collaborative Review Groups Centres Steering Group Methods Groups Fields The Consumer Network
Cochrane Collaboration Collaborative Review Groups Centres Steering Group Methods Groups Fields The Consumer Network
Cochrane Centres Canadian Nordic San Francisco German UK Dutch French Iberoamerican Italian San Antonio Chinese New England Brazilian South African Australasian
Cochrane Centres • Help organise and register review groups • Facilitate collaboration among reviewers • Provide training and consultation • Establish liaisons • Promote the Cochrane Collaboration • Provide unique contribution
Cochrane Collaboration Collaborative Review Groups Centres Steering Group Methods Groups Fields The Consumer Network
Review Groups48 registered, 1 possible • Focus • Treatment of disease or health problems • Emphasis on clinical outcomes • Emphasis on rigorous data
Acute respiratory infections Airways Anaesthesia Back Breast cancer Colorectal cancer Consumers and communication Cystic fibrosis and genetic disorders Dementia & cognitive improvement Depression, anxiety & neurosis Developmental, psychosocial and learning problems Drugs and alcohol Ear, nose and throat disorders Effective practice and organisation of care Epilepsy Eyes and vision Fertility regulation Gynaecological cancer Heart Hepato-biliary Review Groups
HIV/AIDS Hypertension Incontinence Infectious diseases Inflammatory bowel disease Injuries Lung cancer Menstrual disorders and subfertility Metabolic and endocrine disorders Movement disorders Multiple sclerosis Muskuloskeletal Musculoskeletal injuries Neonatal Neuromuscular disease Oral health Pain, palliative and supportive care Peripheral vascular diseases Pregnancy and childbirth Prostatic diseases and urologic cancers Renal Schizophrenia Review Groups
Sexually transmitted diseases Skin Stroke Tobacco addiction Upper gastrointestinal and pancreatic diseases Wounds Haematological malignancies (possible) Review Groups
Review Group products • Reviews • Specialised register
Review Groups • Reviewers • International group • Review relevant trials on specified health care problems • Long-term commitment
Collaborative Review Group process Systematic Reviewer Systematic Reviewer Systematic Reviewer Editors Review Group Co-ordinator Systematic Reviewer Systematic Reviewer Cochrane Database of Systematic Reviews
Review Manager (RevMan) • Cochrane Collaboration software for: • Preparing and maintaining protocols and reviews • Data analysis • Submitting completed reviews to CDSR
RevMan statistical options • Peto Method • Odds Ratio • Mantel-Haenszel fixed effect and Dersimonian/Laird random effects • Odds Ratio, Relative Risk, Risk Difference • Weighted and Standardised Mean Differences
The Cochrane Library • The Cochrane Database of Systematic Reviews (CDSR) • The Database of Abstracts of Reviews of Effectiveness (DARE) • The Cochrane Controlled Trials Register (CCTR) • The Cochrane Methodology Register
Cochrane Collaboration Collaborative Review Groups Centres Steering Group Methods Groups Fields The Consumer Network
Fields9 registered, 1 possible • Represent a population, group, or type of care that overlaps multiple Review Group areas • Examples: Primary Health Care, Health Care of Older Adults, Complementary Medicine, Vaccines, Rehabilitation and Related Therapies
Methods Groups11 registered, 5 possible • Develop methods and products integral to internal functioning of the Collaboration • Develop state of the art methods for systematic reviews • Examples: Statistical Methods, Economics, Placebo Effects, Informatics
The Consumer Network • Provides consumer input • Helps set priorities • Helps with dissemination
Cochrane Collaboration Collaborative Review Groups Centres Steering Group Methods Groups Fields The Consumer Network
Steering Group • Function • Policy making body of the Cochrane Collaboration • Who • Elected representatives of each of the Collaboration entities (Review Groups, Centres, Fields, Methods Groups, the Consumer Network)
Summary of The Cochrane Collaboration • International collaboration • Prepares, maintains, and disseminates systematic reviews • Diverse internal structure (Review Groups, Centres, Fields, Methods Groups, the Consumer Network)
How to participate • Join a Collaborative Review Group • Join a Field, Methods Group, or the Consumer Network • Handsearch a journal • Identify or provide funding
Future challenges • Recruitment of large numbers of reviewers in all areas of health care • Clinically useful presentation of the Cochrane Database of Systematic Reviews • Efficient and effective communication within the Collaboration • Financial solvency of the organisation
The Nordic Cochrane Centre Rigshospitalet, dept 7112 Blegdamsvej 9 DK-2100 Copenhagen Ø Denmark Phone: +45 35 45 55 71 FAX: +45 35 45 70 07 E-mail: general@cochrane.dk The Cochrane Collaboration For more information: www.cochrane.dk