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Chemistry 501 Handout 11 Biological Membranes and Transport Chapter 11

Dep. of Chemistry & Biochemistry Prof. Indig. Chemistry 501 Handout 11 Biological Membranes and Transport Chapter 11. Lehninger. Principles of Biochemistry. by Nelson and Cox, 5 th Edition; W.H. Freeman and Company. Fluid mosaic model for membrane structure.

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Chemistry 501 Handout 11 Biological Membranes and Transport Chapter 11

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  1. Dep. of Chemistry & Biochemistry Prof. Indig Chemistry 501 Handout 11Biological Membranes and TransportChapter 11 Lehninger. Principles of Biochemistry. by Nelson and Cox, 5th Edition; W.H. Freeman and Company

  2. Fluid mosaic model for membrane structure

  3. Lipid composition of the plasma membrane and organelle membranes of a rat hepatocyte

  4. Glycerophospholipids OH H The backbone of phospholipids

  5. Sphingolipids are derivatives of sphingosine

  6. Sterols have four fused carbon rings Cholesterol

  7. Asymmetric distribution of phospholipids between the inner and outer monolayers of the erythrocyte plasma membrane

  8. Peripheral and Integral Proteins The specificities of phospholipases GPI: glycosyl phosphatidylinositol

  9. Lipid-linked membrane proteins

  10. Transbilayer disposition of glycophorin in an erythrocyte Glycoproteins have covalently attached oligosaccharides

  11. Integral membrane proteins Bacteriorhodopsin, a membrane-spanning protein Halobacterium salinarum categories

  12. 3-D structure of the photosynthetic reaction center of Rhodopseudomonas viridis

  13. Protein Architecture - Secondary Structure A few types of secondary structures are particularly stable and occur widely in proteins. Most prominent: a helix and b conformations. Note: The a helix is not hollow Space-filling model Ball-and-stick model The a helix as viewed from one end, looking down the longitudinal axis Formation of a right-handed a helix Ball-and-stick model of a right-handed a helix, showing the intrachain H bonds The atoms in the center of the a helix are in very close contact

  14. Hydropathy Plots

  15. Membrane proteins with b-barrel structure

  16. Solute transport across membranes

  17. Movement of solutes across a permeable membrane

  18. Movement of solutes across a permeable membrane

  19. Energy changes accompanying passage of a hydrophilic solute through the lipid bilayer of a biological membrane Facilitated diffusion or passive transport

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