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Study cancer disease mechanisms by searching for cancer signaling pathways

Study cancer disease mechanisms by searching for cancer signaling pathways. Songjian Lu, PhD Assistant Professor Department of Biomedical Informatics University of Pittsburgh School of Medicine. Pathway regulates the cell cycle. Pathway regulates the cell death.

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Study cancer disease mechanisms by searching for cancer signaling pathways

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  1. Study cancer disease mechanisms by searching for cancer signaling pathways Songjian Lu, PhD Assistant Professor Department of Biomedical Informatics University of Pittsburgh School of Medicine

  2. Pathway regulates the cell cycle Pathway regulates the cell death Pathway regulates the proliferation The major goal of my current research Genes related to the cell cycle • Re-construct the signaling pathways related to cancer development. • Understand the cancer disease mechanism. • Provide the potential candidates for target therapy. Genes related to the proliferation Genes related to the cell death The basic method • Apply the reverse engineering technology: • Use genes that were differentially expressed as the readout of perturbed pathways to search for up-stream pathways. • Design efficient exact algorithms to solve the NP-hard problems in our models, which guarantees the optimal solutions of the models.

  3. Examples of research results - 1 • Wet-lab verification: The siRNAs of BCL2L11 and CDH9 promoted the cell migration. Hence, they are the potential candidates for treating tumor metastasis. • Computational results: The mutations of BCL2L11 and CDH9 are associated with the expression change of a gene signatures that are abnormally expressed in metastatic tumors.

  4. Examples of research results - 2 • Computational results: The mutation of TP53, the amplifications of MED1, YWHAZ, and PTK2 affect the cell DNA repair, mitosis, cell cycle etc. • Wet-lab verification: The knockdown of MED1, PTK2 and YWHAX thwart the growth of cancer cells. Hence, they are the potential candidates for target therapy.

  5. Recent publications Research funding

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