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Ebola Hemorrhagic Fever

Ebola Hemorrhagic Fever. Cory Breaux. Ebola Hemorrhagic fever is a disease caused by any of the four virulent strains of the Ebola virus. http:// students.cis.uab.edu /sajayi11/ebola_1.jpg. Hemorrhagic fevers are diseases causing excessive bleeding, fever, and frequently death.

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Ebola Hemorrhagic Fever

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  1. Ebola Hemorrhagic Fever Cory Breaux

  2. Ebola Hemorrhagic fever is a disease caused by any of the four virulent strains of the Ebola virus http://students.cis.uab.edu/sajayi11/ebola_1.jpg

  3. Hemorrhagic fevers are diseases causing excessive bleeding, fever, and frequently death http://ars.els-cdn.com/content/image/1-s2.0-S0966842X0400188X-gr1.jpg

  4. Other Hemorrhagic diseases include yellow fever, Dengue fever and Marburg virus http://hardinmd.lib.uiowa.edu/pictures22/cdc/PHIL_2176_lores.jpg

  5. Ebola is a member of the filovirus family, which was first identified in 1967 http://mbe.oxfordjournals.org/content/14/8/800.long

  6. The natural reservoir is unknown, although some species of bats carry the virus http://www.ecohealthalliance.org/writable/rich_text_editor/images/hammer_headed_bat.jpg

  7. The virus particle, recognized by “Shepherd’s crook” shape, contains a single DNA strand http://students.cis.uab.edu/sajayi11/ebola.jpg

  8. The first outbreak of Ebola was 1976 in the Democratic Republic of the Congo https://eee.uci.edu/clients/bjbecker/PlaguesandPeople/week10d.html

  9. All outbreaks have been in sub-Saharan Africa, and have been small (<318 cases) http://www.cdc.gov/ncidod/dvrd/spb/images/ebola/ebolamap.jpg

  10. There have been 3 incidences of exposure in the US, but all have occurred in labs

  11. It is transmitted from animals to humans or human to human via bodily fluids http://www.cdc.gov/ncidod/dvrd/spb/mnpages/icposters/index.htm

  12. Thus, healthcare workers are at the greatest risk for acquiring the disease http://www.cdc.gov/ncidod/dvrd/spb/mnpages/icposters/index.htm

  13. Ebola enters the body via mucous membranes, skin abrasions or contaminated needles http://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click%20on%20image%20to%20zoom&p=PMC3&id=2615158_DMM000471F1.jpg

  14. Earliest symptoms are flu-like • Around day 5, characteristic rash appears http://assets3.scripps.org/encyclopedia/graphics/images/en/17160.jpg

  15. Infection then becomes systemic, leads to apoptosis, hemorrhage, shock and death

  16. There is no treatment available – only containment stops spread http://www.who.int/features/marburg2/06.jpg

  17. No vaccine currently exists, and the disease is difficult to distinguish early in an outbreak http://physiciansforhumanrights.org/assets/images/panzi-ward.jpg

  18. Lethality makes research difficult in the lab and speed makes it difficult to assess epidemiologically during outbreaks http://upload.wikimedia.org/wikipedia/commons/8/8e/Positive-pressure_biosafety_suit.jpg

  19. References • Bente, D., J. Gren, J. E. Strong, and H. Feldmann. "Disease Modeling for Ebola and Marburg Viruses." Disease Models and Mechanisms 2.1-2 (2009): 12-17. PubMed. National Institutes of Health. Web. 30 Oct. 2012. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2615158/>. • "Ebola Haemorrhagic Fever." World Health Organization, Aug. 2012. Web. 30 Oct. 2012. <http://www.who.int/mediacentre/factsheets/fs103/en/index.html>. • "Ebola Hemorrhagic Fever Information Packet." CDC Special Pathogens Branch - Ebola Hemorrhagic Fever. Centers for Disease Control and Prevention, 2009. Web. 30 Oct. 2012. <http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/Fact_Sheets/Ebola_Fact_Booklet.pdf>. • "Filoviruses." CDC Special Pathogens Branch. Centers for Disease Control and Prevention, n.d. Web. 30 Oct. 2012. <http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/filoviruses.htm>. • "Interim Guidance for Managing Patients with Suspected Viral Hemorrhagic Fever in U.S. Hospitals." CDC Special Pathogens Branch - Ebola Hemorrhagic Fever. Centers for Disease Control and Prevention, 19 May 2005. Web. 30 Oct. 2012. <http://www.cdc.gov/ncidod/dvrd/spb/pdf/vhf-interim-guidance.pdf>. • Rollin, Pierre E. "Viral Hemorrhagic Fevers." CDC Yellow Book 2012. Centers for Disease Control and Prevention, 1 July 2011. Web. 30 Oct. 2012. <http://wwwnc.cdc.gov/travel/yellowbook/2012/chapter-3-infectious-diseases-related-to-travel/viral-hemorrhagic-fevers.htm>. • Suzuki, Y., Gojobori, T. “The Origin and Evolution of Ebola and Marburg Viruses.” MolBiolEvol 14(8) (1997): 800-806. PubMed. National Institutes of Health. Web. 6 November 2012. <http://mbe.oxfordjournals.org/content/14/8/800.long>. • Zampieri, Carisa A., Nancy J. Sullivan, and Gary J. Nabel. "Immunopathology of Highly Virulent Pathogens: Insights from Ebola Virus." Nature Immunology 8.11 (2007): 1159-164. Academic OneFile. Gale Cengage Learning. Web. 30 Oct. 2012. <http://go.galegroup.com/ps/i.do?action=interpret&id=GALE%7CA190699659&v=2.1&u=unc_main&it=r&p=AONE&sw=w&authCount=1>.

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