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Ebola Hemorrhagic Fever

Ebola Hemorrhagic Fever. Anderson Coates Michael Mastropole. Discovery. Three initial outbreaks 1976 in Sudan E. Sudan 1976 in the Democratic Republic of the Congo E. Zaire 1979 in Sudan E. Sudan Outbreak occurred in the same factory as first outbreak. Virus Strains.

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Ebola Hemorrhagic Fever

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  1. Ebola Hemorrhagic Fever Anderson Coates Michael Mastropole

  2. Discovery • Three initial outbreaks • 1976 in Sudan • E. Sudan • 1976 in the Democratic Republic of the Congo • E. Zaire • 1979 in Sudan • E. Sudan • Outbreak occurred in the same factory as first outbreak

  3. Virus Strains • 5 different strains • E. Sudan • E. Zaire • E. Ivory Coast • Only one confirmed case • E. Reston • Non pathogenic to humans • E. Bundibugyo

  4. Ebola virus • Member of Filoviridae • Pleomorphic • RNA virus • Genome has seven open reading frames • Code for structural proteins, glycoproteins, nucleoproteins, and polymerase

  5. Through blood to blood contact • Undersupplied and undertrained health-care staff • Reusing needles and bloody gloves in hospitals Transmission

  6. Natural Reservoir • Currently unknown • Sub-Saharan Africa non-human primate population • Possibly local bat population

  7. Symptoms (Days 1-10) • Replication period • Inside the body’s monocytes, macrophages, and dendritic cells • No visible symptoms, but contagious

  8. Symptoms (Days 11-14) • Body recognizes infection and responds • fever, headache, muscle pain, conjunctivitis, and abdominal pain • Virus attaches to blood vessel walls

  9. Symptoms (Days 15-19) • Virus attacks connective tissue • Blood pools under skin • nausea, blood in vomitand diarrhea, and hemorrhaging from the mouth, nose, and other body openings • Hypovolemic shock causing death

  10. Ebola Documentary Trailer • http://www.youtube.com/watch?v=A0n5dLiBJL8

  11. Sources • (2009). ViralZone. Retrieved Apr. 9, 2010, from Swiss Institute of Bioinformatics, Switzlerland. Web site: http://www.expasy.ch/viralzone/all_by_species/23.html. • (2009). Questions and Answers about Ebola Hemorrhagic Fever. Retrieved Apr. 8, 2010, from Centers for Disease Control and Prevention, Atlanta,GA. Web site: http://www.cdc.gov/ncidod/dvrd/Spb/mnpages/dispages/ebola/qa.htm. • (2010). Syndromic Surveillance as an Early Warning System for Biological Attacks. Retrieved Apr. 8, 2010, from Medscape CME. Web site: http://cme.medscape.com/viewarticle/456526_11.

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