1 / 24

The T-Cell Receptor

The T-Cell Receptor. MHC Restriction TCR Structure & Function Genetic Generation of TCR Diversity Thymus T-cell "Education" and Immunological Tolerance. Folder title: Receptor. November 15, 2006. TCRTitle. Comparison of T-Cell Receptors (TCR) and Antibodies: Differences.

dea
Download Presentation

The T-Cell Receptor

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. The T-Cell Receptor MHC Restriction TCR Structure & Function Genetic Generation of TCR Diversity Thymus T-cell "Education" and Immunological Tolerance Folder title: Receptor November 15, 2006 TCRTitle

  2. Comparison of T-Cell Receptors (TCR)and Antibodies:Differences Antibody Can be membrane bound; Secreted in large amounts. Recognizes Antigen alone: Soluble or particulate No accessory molecules involved Not MHC Restricted TCR Remains Membrane-bound. Present in small amounts. Recognizes binary complex: Antigen and MHC Protein Associated with CD3, CD4, & CD8 AccessoryMolecules Is MHC Restricted TCRvsAb1

  3. Comparison of T-Cell Receptors (TCR)and Antibodies:Similarities TCR and Ab Rearrange V, J, and (Sometimes) D Germ-line Genes, link these, and join them to C-region Genes, during somatic cell differentiation. (V, J, D and C region germ-line genes are different for TCR vs Ab) Have Complementarity Determining Regions (CDR's) that are hypervariable Recognize an enormous variety of antigenic determinants TCRvsAb2

  4. See Figure 8-15, Kuby, 6th Edition p. 207

  5. MHCRestr Self-MHC Restriction of TCR Kuby, 6th Edition, Fig 9-1, p. 224

  6. Figure 10-5. Top. Kuby, 6th Edition, p. 249

  7. Figure 10-5. Bottom. Kuby, 6th Edition, p. 249

  8. See Figure 9-3, Right Side, Kuby, 6th Edition, p. 226

  9. (costimulates) costimu (inhibits)

  10. Generation of Alpha and Beta Subunits of TCR from Germ-line DNAFigure 11-6, Kuby 3rd Edition

  11. See Table 9-3, Kuby, 6th Edition, p. 229

  12. Allo-Reactivity of T-Cells: orWhy Do T-cells Frustrate Transplant Surgeons? Figure 11-1 Kuby, 3rd Edition AlloKill

More Related