( Center for Systems Biology) Prof. Wolfgang Driever Coordinator of Center Foundation

1. (Center for Systems Biology)Prof. Wolfgang DrieverCoordinator of Center Foundation

2. Zentrum für Biosystemanalyse ZBSACenter for Systems Biology • Scientific concept ZBSA • The ZBSA Core Facilities / Building • Scientific Environment - Freiburg Systems Biology • Specific Questions from WTEC

3. Systems Biology • Standardized systems • Aquisition of quantitative time resolved data • Data analysis - Modell building

4. Research Focus ZBSA Freiburg Standardized systems Aquisition of quantitative time resolved data Data analysis - Modell building

5. Center for Systems Biology - ZBSA • Established within framework of State of Baden-Württemberischen initiative “Life Science Centers” • Interdisciplinary research. • Bringing together expertise in data aquisition, data management, and model building for the analysis of complex biological systems. • Genomics • Proteomics • Biological Imaging • Metabolomics • Integration with bioinformatics groups

6. Scientific Organization of the ZBSA

7. Research Area A: Cellular Systems • Focus on single cell systems as independent regulatory unit. • Analysis of complex regulatory circuitries. • Using exemplary cellular systems. • Example: Liver cells

8. Research Area B: Regulatory Networks - Supracellular Organization • Aims at understanding the complexity of regulatory interactions which control differentiation of defined cell types, organization of cells into organs, as well as complex multicellular systems. • Examples: • Regulatory networks during cell differentiation and organogenesis • Understanding complex neural circuitries / activity patterns in the brain

9. Research Area B: Regulatory Networks - Supracellular Organization • Example: Gene Regulatory Networks • (Model of endomesoderm development by E. Davidson Lab, H. Bolouri; http://www.its.caltech.edu/-mirsky/endomesoderm.htm) • Freiburg: Focus not only on transcription circuitries but on signaling systems: • Link to Freiburg SFB 592: Signaling Mechanisms in Embryogenesis and Organogenesis

10. Research Area C: Metabolomics Aims at establishing models for metabolite flow by profiling flow of low molecular weight metabolites and secondary metabolites. Analysis of biochemical kinetics and transport processes Examples: - “Golden Rice” metabolite flow vitamine A synthesis in rice - Metabolite flow in large plants (Department of Forestry Research and Environmental Sciences)

11. Systems Biology - Model Building

12. Systems Biology - Model Building

13. Z BSA Z fB I Z e n tr um f ü r Z e n tr um f ü r B io s ys te m - B ioin fo r m a t i k a n aly s e Data Analysis - Modelling - „Systems Biology“ • Interactions among Freiburg Research Centers Biosystemanalyse Data Analysis and Modelling Bioinformatics ZfBI ZBSA FDM

14. Interactions with Mathematical - Model Building Center

15. ZBSA Foundation Committee ... represents integration of both biomedical and plant systems biology „Biomedical Models“ Baumeister Driever Walz Peters „Plant Sciences“ Palme Haehnel Rennenberg Systems Biology Timmer, NN Bioinformatics Hess, NN Technologies Nitschke Sparna NN

16. Central Position of ZBSA within Freiburg Life Sciences MPI Biotech-Park molekular- organismische Forschungsbereiche molekulare & molekularbiologisch zellbiologische Forschungsbereiche Informatik Mikrosystemtechnik ZBSA Biologie I, II, III klinische Forschungsbereiche Kliniken Informatik Mikrosystemtechnik Datenanalyse Forstwissenschaften Zentrum für Biosytemanalyse FDM Anatomie Biochemie Physiologie Chemie&Pharmazie Physik

17. The ZBSA building site within the life sciences campus

18. ZBSA State of Baden-Württemberg: 21 Mio € Building complete fall 2006 ca. 90 Scientists ca. 3000 qm

19. ZBSA: Integration of Data Acquisition and Modelling OG1 Systems Biology Bioinformatik Modellbildung Sozial- bereich Labore S1 / S2: quantitative Datenerhebung OG2

20. ZBSA: Integration of Data Acquisition and Modelling OG1 Systems Biology Bioinformatik Modellbildung Sozial- bereich Labore S1 / S2: quantitative Datenerhebung OG2

21. ZBSA: Integration of Data Acquisition and Modelling OG1 Systems Biology Bioinformatik Modellbildung Sozial- bereich Labore S1 / S2: quantitative Datenerhebung OG2

22. ZBSA: Integration of Data Acquisition and Modelling OG1 Systems Biology Bioinformatik Modellbildung Sozial- bereich Labore S1 / S2: quantitative Datenerhebung OG2

23. ZBSALocal Scientific Environment in Freiburg

24. New Faculty of Informatics & Computer Sciences

25. New Freiburg Institute of Microsystem Technology

29. ZBSAPlans for integration of ZBSA into the trinational research area

32. WTEC Questions • Successful approaches • Modelling by Timmer et al. • Critical failures • ! too young to have failed ! • Technology challenges • High quality time resolved „near life“ data acquisition • Interactions Academia, Industry, Government • Strong support from goverment (State / Federal) • Industry initial contacts

33. WTEC Questions • Plans for future • establish ZBSA as outlined • Expectations • obtain models with predictive value • biomedical area „making use of theory“ • environmental sciences and agroeconomics optimizing use of ressources • Time line • long range • Education • excellent integration into graduate programs Biology, Molecular Medicine, Informatics & Computer Sciences , Mathematics

34. Contacts ZBSA • Email: • zbsa@biologie.uni-freiburg.de • WWW (under construction!!) • www.zbsa.uni-freiburg.de