1 / 10

Chemical Biology

Chemical Biology. Chem258, Spring 2009. Chem258: chemical biology. Instructor Martin Case, Cook A321 martin.case@uvm.edu Meeting times MWF 9:35 - 10:25 am, Angell 104 Class website http://www.uvm.edu/~mcase/courses/chem258. Course structure.

dean-hart
Download Presentation

Chemical Biology

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Chemical Biology Chem258, Spring 2009

  2. Chem258: chemical biology • Instructor • Martin Case, Cook A321 • martin.case@uvm.edu • Meeting times • MWF 9:35 - 10:25 am, Angell 104 • Class website • http://www.uvm.edu/~mcase/courses/chem258

  3. Course structure • Based on student presentations (2 per student) • A paper that interests you • Extensive background not required • Powerpoint preferred • Hard copy for class to read and prepare for… • Discussion • 1-2 class periods • Be prepared to ask (and answer) questions • Instructor in the hot seat • Grading is based on presentations and participation in discussion sessions

  4. Time commitment • 3 credit class = 10 hours per week • 3 hours in class leaves 7 hours per week • 3 hours reading and researching other students’ presentations leaves 4 hours per week, 48 hours over the semester • 2 presentations per student over the course of the semester • Expect to spend about 24 hours on each presentation • 24 hours??? • 6 hours reading and researching your paper • 18 hours to prepare your presentation (it can easily take an hour per slide)

  5. What is chemical biology? • The application of synthetic chemical techniques and tools to the study and manipulation of biological systems

  6. What is chemical biology not? • Biochemistry • chemistry of biological systems • relatively few classes of reactions • mediated by enzymes • Bio-organic chemistry • extension of organic chemistry toward biology • eg synthesis of natural products

  7. Some basic principles • Chemoselectivity • Biologically inherent (thiols) • Exogenous via promiscuous systems (azido sugars, azidohomoalanine) • Molecular recognition • Stereocomplementarity • H-bonding • Hydrophobic interactions • Ultimately everything is aqueous

  8. Why does it matter? • Drugs • Modern medicinal chemistry (inhibitor design) is essentially chemical biology • Different drugs • Antibody therapeutics • Interference RNAs • Probes and diagnostics • Tumor cell labeling • Enzyme and metabolite tracking • 21st century medicine • Proteomics and glycobiology • Catalysis

  9. Chemical biology publications since 1990 record count year

  10. Chemical biology journals • Chemical Biology (ACS) • Nature Chemical Biology • Journal of Chemical Biology (Springer) • ChemBioChem • Chemistry & Biology • Chemical Biology (RSC) • chemical biology articles from RSC publishing

More Related