neoadjuvant chemoradiotherapy for rectal cancerneoadjuvant chemoradiotherapy for rectal cancer

Objectives. CaseRectal Cancer StagingIndications for Neoadjuvant ChemoradiotherapyNeoadjuvant RadiotherapySurgical ApproachesEvidence to Support Neoadjuvant ApproachOther neoadjuvant chemoradiotherapy regimens under investigationConclusions. Case. 50 y/o F with h/o rectal bleeding found to have a rectal mass with biopsy for moderately-differentiated adenocarcinoma.CT ? No rectal lesion seen; no evidence of metastatic diseaseTRUS ? Tumor 2.5 cm in diameter

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OLD APPROACH TO RECTAL CANCER

Surgical resectionPathology assessment and estimation of riskTreatment based upon classical TNM factorsPostoperative concurrent chemoradiation. OLD APPROACH TO RECTAL CANCER. NIH consensus conference. Adjuvant therapy for patients with colon and rectal cancer JAMA, Sep 1990; 264: 1444 - 1450. .

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Treatment of Recurrent rectal Cancer

Pain and quality of life after treatment in patients with locally recurrent rectal cancerEsnaola NF. Cantor SB. Johnson ML. Mirza AN. Miller AR. Curley SA. Crane CH. Cleeland CS. Janjan NA. Skibber JM. Journal of Clinical Oncology. 20(21):4361-7, 2002 Nov 1. . Article. Difficult treatment areaAf

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Cancer Colo-rectal

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BREAST CANCER Neoadjuvant Chemotherapy

BREAST CANCER Neoadjuvant Chemotherapy. Interest of neoadjuvant CT. % of patients with distant relapse. Tumor N. of nodes diameter 0 1-3 > 3 1.9 cm 21 26 - 3.2 cm 18 48 58 4.2 cm 32 58 74 6.2 cm 32 71 79 9 cm 62 - - . Need for a systemic treatment even in small tumors.

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Rectal Cancer: Advanced Technologies

Rectal Cancer: Advanced Technologies. Chris Willett, M.D. Department of Radiation Oncology Duke University Medical Center Durham, NC. Gastric Intergroup 0116: RT Considerations. 35% of initially submitted RT plans: Major deviations (2/3 undertreatment) 2 D Therapy: AP/PA.

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Consequences of Treatment for Rectal Cancer

Consequences of Treatment for Rectal Cancer. Gillian Knowles, Rachel Haigh, Catriona McLean, Hamish Phillips, Malcolm Dunlop, Farhat Din. Background. People can experience distressing symptoms following treatment for rectal cancer

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Neoadjuvant Chemotherapy in Ovarian Cancer

Neoadjuvant Chemotherapy in Ovarian Cancer. Key issues in trial design. Key Issue #1. What are the most current consensus recommendations on developing large phase III trials in ovarian cancer?.

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Neoadjuvant therapy of rectal cancer – how can we make it better? Claus Rödel

Neoadjuvant therapy of rectal cancer – how can we make it better? Claus Rödel Department of Radiotherapy University of Frankfurt, Germany. Honoraria: Roche, Sanofi-Aventis. Research Funding: Merck Roche. O U T L I N E. How can we make it more efficient (or less toxic)?

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Multimodality Therapy of Rectal Cancer

Multimodality Therapy of Rectal Cancer. Robert D. Madoff, MD University of Minnesota. rectal cancer clinical issues. colostomy or anastomosis? local or radical surgery? functional outcomes? neoadjuvant therapy?. rectal cancer therapy. morbidity mortality function. optimal cure rate.

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Rectal cancer

Rectal cancer. OLD APPROACH TO RECTAL CANCER. CURRENT APPROACH TO RECTAL CANCER. Surgical resection Pathology assessment and estimation of risk Treatment based upon classical TNM factors Postoperative concurrent chemo-radiation. Staging workup (MRI,TRUS,PET CT) MDT discussion

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Chemoradiotherapy for Rectal cancer

Chemoradiotherapy for Rectal cancer. Dr. A . Sun Myint Lead Clinician GI Tumour Group Clatterbridge Centre for Oncology. Association of Coloproctology of Great Britain and Ireland M62 Coloproctology Course - March 23 rd 2007. Background.

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Preoperative chemoradiotherapy WITH CVI 5FU is the standard of care for T3-4 rectal CANCER

The Impact of Capecitabine and Oxaliplatin in the Preoperative Multimodality Treatment of Patients with Carcinoma of the Rectum: NSABP R-04.

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Management of rectal cancer

Mediterranean School of Oncology Rome, November 23, 2012. Management of rectal cancer. CARMINE PINTO Oncologia Medica Policlinico S.Orsola-Malpighi Bologna. Background - 1.

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Colon Rectal Cancer

They immediately put 74 cc back into me, via an IV drip. The remaining 6 cc will be expanded to increase the number of stem cells from approximately 5 million to 100-200 million. Half to all of the expanded cells will be put back into me again, via IV with the other half to be frozen for future use.

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Neoadjuvant SystemicTreatment Strategies for Breast Cancer

Neoadjuvant SystemicTreatment Strategies for Breast Cancer. Donald W. Northfelt, MD, FACP Professor of Medicine Mayo Clinic College of Medicine Associate Medical Director, Breast Clinic Mayo Clinic Arizona northfelt.donald@mayo.edu. DISCLOSURES. no conflicts of interest

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Neoadjuvant Chemotherapy in Breast Cancer

Neoadjuvant Chemotherapy in Breast Cancer. Pr Hamouda Boussen MD Department of medical oncology Institut Salah Azaiz. Tunis. Post-graduate course of Mediterranean Task Force for Cancer Control and Mediterranean School of Oncology. Hotel El Mechtel. November 14th, 2008. Tunis.

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CPAC Rectal Cancer Project

CPAC Rectal Cancer Project. The webinar will begin momentarily. All participant lines will be muted during the presentations. Following the presentations, all participant lines will be unmuted for discussion and question period. CPAC Rectal Cancer Project (2014-2017).

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