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Introduction to H IV Vaccines

Introduction to H IV Vaccines. Definition. A vaccine is a substance that teaches the body’s immune system to recognize and protect against a disease caused by an infectious agent. A vaccine primer. 200 years of vaccines Common vaccines Types of immunity: humoral (antibody) and cell-mediated

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Introduction to H IV Vaccines

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  1. Introduction to HIV Vaccines International HIV/AIDS Toolkit

  2. Definition • A vaccine is a substance that teaches the body’s immune system to recognize and protect against a disease caused by an infectious agent. International HIV/AIDS Toolkit

  3. A vaccine primer • 200 years of vaccines • Common vaccines • Types of immunity: humoral (antibody) and cell-mediated • An ideal HIV vaccine • Preventative or therapeutic? • Vaccine development stages International HIV/AIDS Toolkit

  4. State of Vaccine Research • First trial in 1987 • 30 products tested • 60 clinical trials • 2 phase III trials • 1% of global health R&D • In Canada, only AIDSVAX trial • $2.14 million in Canada on research International HIV/AIDS Toolkit

  5. State of Canadian vaccine research • CANVAC • CIHR • CIDA grant to IAVI • Globally: a few pharmas, universities and governments • A narrow pipeline! International HIV/AIDS Toolkit

  6. Impact on the epidemic Low-efficacy: • Delivered to « high-risk » population • Level of awareness of vaccines • Level of trust of vaccines • Attitudes towards HIV/AIDS • Stigma & discrimination International HIV/AIDS Toolkit

  7. Impact on the epidemic Low-efficacy (2) • Rates of coverage • Vaccine optimism • Combination prevention High efficacy • Very similar issues! No efficacy BUT still OK! International HIV/AIDS Toolkit

  8. Who’s Who • International AIDS Vaccine Initiative (IAVI) • Canadian AIDS Society (CAS) • Canadian HIV/AIDS Legal Network • Canadian Network for Vaccines and Immunotherapeutics (CANVAC) International HIV/AIDS Toolkit

  9. Canadian HIV Vaccines Plan • 1) Ensuring Canada’s commitment to the development of HIV vaccines • 2) Ensuring public engagement • 3) Ensuring integrated strategic plans for HIV vaccine research and development • 4) Ensuring equitable vaccine access and delivery International HIV/AIDS Toolkit

  10. Becoming involved • Getting and disseminating information • Subscribing to IAVI Report or VAX • Advocating for vaccine development • Raising information in your community • Participating in development of Canadian HIV Vaccines Plan International HIV/AIDS Toolkit

  11. Sources of Information • www.iavi.org IAVI Report, VAX • www.avac.org Handbook, reports • www.cdnaids.ca Basics, advocacy updates • www.aidslaw.ca Discussion paper, info sheets • www.icaso.org Primers • www.canvacc.org Vaccines, R&D International HIV/AIDS Toolkit

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