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Cortical structures

Cortical structures eg pain, fear, sights, smells, raised ICP: Benzodiazepines & steroids. ?GABA. Vomiting centre levomepromazine Hyoscine Cyclizine*. M H1 5-HT2 . Vestibular Apparatus Levomepromazine Cyclizine* Hyoscine.

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Cortical structures

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  1. Cortical structures eg pain, fear, sights, smells, raised ICP: Benzodiazepines & steroids ?GABA Vomiting centre levomepromazine Hyoscine Cyclizine* M H1 5-HT2 Vestibular Apparatus Levomepromazine Cyclizine* Hyoscine Chemoreceptor trigger zone (CTZ) eg drugs, toxins, biochemical upset Haloperidol* Metoclopramide Levomepromazine H1 M D25-HT3M Autonomic nervous system (vagus nerve) eg pharyngeal irritation, gastric/bowel obstruction, constipation Levomepromazine Metoclopramide* Ondansetron N&V Key: Site Cause Antiemetic [Highest receptor affinity top] [*usual first line] J Adam 2006 M D2 5-HT3 Receptors

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