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(1). NEONATAL TREATMENT 6-OHDA-Lesioned or Sham-Lesioned. ( ADULT TREATMENT ). Saline. SKF-38393. Single Injection. Multiple Injections. Single Dose. Multiple Doses. Sacrificed at 15, 30, 60, 120 min 3, 7 d. Sacrificed at 15, 60, 120, 360 min 3, 7, 14*, 21*,

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  1. (1) NEONATAL TREATMENT 6-OHDA-Lesioned or Sham-Lesioned (ADULT TREATMENT) Saline SKF-38393 Single Injection Multiple Injections Single Dose Multiple Doses • Sacrificed at • 15, 30, 60, • 120 min • 3, 7 d • Sacrificed at • 15, 60, 120, • 360 min • 3, 7, 14*, 21*, • 36* days • At 36 d, rats • given additional • dose SKF-38393 • and killed 7 days • later* • Sacrificed at • 15, 60, • 120 min • 3, 7 d • Sacrificed at • 15, 60, 120, • 360 min • 3, 7 14, 21, • 36 days • At 36 d, rats • given a dose • of SKF-38393 • or saline and • killed 7 days • later (2)SL327 Pre-treatment a) SL-SKF→ SL-SKF→ SL-SKF→ Veh.-SKF →Sacrificed b) Veh.-SKF→Veh.-SKF→Veh.-SKF→Veh.-SKF→Sacrificed c) Veh.-Saline→Veh.-Saline→Veh.-Saline→Veh.-Saline→Sacrificed (3) SCH-23390, Ketanserin, MK-801, and CGS-19755 Pre-treatment a) Antag.-SKF→Antag.-SKF→Antag.-SKF→Antag.-SKF→Sacrificed b) Antag.-Saline→Antag.-Saline→Antag.-Saline→Antag.-Saline→Sacrificed c) Saline-SKF→Saline-SKF→Saline-SKF→Saline-SKF→Sacrificed d) Saline-Saline→Saline-Saline→Saline-Saline→Saline-Saline→Sacrificed

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