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Overview of the Federally Funded Research and Development Center at Frederick

Overview of the Federally Funded Research and Development Center at Frederick. James H. Doroshow , M.D. Deputy Director for Clinical and Translational Research National Cancer Institute, NIH.

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Overview of the Federally Funded Research and Development Center at Frederick

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  1. Overview of the Federally Funded Research and Development Center at Frederick James H. Doroshow, M.D. Deputy Director for Clinical and Translational Research National Cancer Institute, NIH

  2. The Federally Funded Research and Development Center at The Federally Funded Research and Development Center at Frederick • Unique national resource – the only FFRDC dedicated principally to biomedical research • Administered by the NCI whose mission it is to help people live longer, healthier lives by supporting research to reduce the incidence of cancer and to improve the outlook for patients who develop cancer • Together, along with the broader research community, we pursue highly innovative basic, applied, and translational biomedical research

  3. The Federally Funded Research and Development Center at The T Frederick National Lab for Cancer Research • The FFRDC operates as the Frederick National Laboratory for Cancer Research (FNLCR) • The FNLCR, positioned alongside labs at the NCI, provides opportunity for the research community to leverage a unique combination of technical expertise, physical infrastructure, and support services • The convergence of scientific possibility and the need for more complex partnerships make this an ideal time for the National Lab to underpin the nation’s cancer research activities

  4. The Federally Funded Research and Development Center at The Signature Projects at the FNLCR • Not a one-size-fits-all approach – scientific projects are developed based on the opportunities, needs, and leveraged resources • Framework of the National Lab, coupled with the special authorities of the FFRDC, enable the pursuit of new scientific opportunities through flexible, rapid, collaborative approaches • Three examples of current or proposed projects: • RAS • Cryo-EM • Preclinical Models

  5. The Federally Funded Research and Development Center at Thee RAS Initiative • Intended to deepen knowledge of several aspects of RAS genes and proteins – more about this project this afternoon • Hub and Spoke Model – National Lab acts as the hub that connects to the spokes, which includes experts at labs across the country • Projects are conducted at the National Lab with over 1600 researchers invited to collaborate • This approach fills gaps in scientific knowledge and applies the latest technological advances and expertise to the challenge of RAS

  6. MicroscopyCryo-Electron Microscopy(Cryo-EM) • Proposed initiative discussed at Frederick National Laboratory Advisory Committee meeting 9/30/15 • Goal is to solve the structure of molecules important for cancer research • Intends to broadly support the growth of Cryo-EM through the development of a national resource providing microscope time and expertise • Core services model – Core facility would be at the National Lab but projects would be conducted at institutions across the country

  7. Preclinical Models • Proposed initiative discussed at Frederick National Laboratory Advisory Committee meeting 9/30/15 • Hybrid model • Develop representative human cancer model systems including novel human cell lines for the research community • Conduct research at the National Lab using preclinical models (e.g., determining the effectiveness of new combinations of novel molecularly targeted investigational agents)

  8. Another approach: Laboratory Directed Exploratory Research Fund • Up to $1M to fund National Lab pilot projects • Fund Objectives • Enhance the innovation, creativity, originality, and quality of research activities at the National Lab • Facilitate collaborations within FNLCR • Engage universities and encourage collaboration and strategic interactions • Enable demonstration of exploratory “proof of concept” projects which will lead to durable funding through contract or grant mechanisms

  9. The Frederick National Lab for Cancer Research • Partnership with the FNLCR is critical to the NCI • NCI looks forward to expanding that partnership to provide for greater engagement with the biomedical research community • Together we can help people live longer, healthier lives by reducing the incidence of cancer and improving the outlook for patients who develop it

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