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Physiology and the Growth of virus

Physiology and the Growth of virus. Dr. A. Aziz Djamal MSc.DTM&H,sPmk (k). What is a Virus. A non-cellular micro-organism with contain genome ( DNA or RNA ) and protein coat ,lipid or glycoprotein Virus ( latin ) mean Poison/ toxin.

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Physiology and the Growth of virus

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  1. Physiology and the Growth of virus Dr. A. Aziz DjamalMSc.DTM&H,sPmk(k)

  2. What is a Virus A non-cellular micro-organism with contain genome ( DNA or RNA ) and protein coat ,lipid or glycoprotein Virus (latin) mean Poison/ toxin

  3. Viral Growth ?Is it true?Actually Growth-increase in size

  4. History 1901 FROSCH and LOFFLER- Foot and Mouth Disease IWANOSKY Tobacco mozaic virus Ultrafiltrable agent

  5. Characteristic No Cellular organel for metabolism. esp. Ribosome. 2. No growth and no energy yielding mechanism. Obligate Intracellular. Resistant to antibiotics. CMI play more in immunity. Size relatively very small – nanometer

  6. Method of reproduction No living activities outside living cells. Choose the appropriate cell depend on specific receptor. A Species virus choose specific target cell. Process of entering the target cell : Adsorbtion/attchment, Penetration, Uncoating, Transcription-Replication, Synthesis of Viral components, Assembly, New viral particles, Host cell burst/Budding.

  7. Viral Classification Depend much on the kind of cell as target of any virus : Animal Virus , Include human virus. Plant Virus. Bacterial Virus ( Bacteriophage).

  8. Viral Morphology Symetry Eicosahedral Hellical Special type

  9. Further Classification Many ways: The way of transmission : Arbovirus Size and genome : Picorna virus. Target organ : Hepatitis virus. Etc.

  10. What happen in the target cell Cell death- Cellular burst – CPE. Un-assembly protein – Inclusion body : Negri body Paschen Body. 3. Integration/Insertion of viral genome to genome host cell—Cellular genetic and phenotypic change—hyperplasia/Oncogenic development.

  11. Thank you

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