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Lecture 10 – Second Messengers IV – Niric Oxide, cGMP , and ROS Signalling

Lecture 10 – Second Messengers IV – Niric Oxide, cGMP , and ROS Signalling. BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F. CSB Fig 02:01 Cell signalling pathways .

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Lecture 10 – Second Messengers IV – Niric Oxide, cGMP , and ROS Signalling

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  1. Lecture 10 – Second Messengers IV –Niric Oxide, cGMP, and ROS Signalling BIOL 5190/6190 Cellular & Molecular Singal Transduction Prepared by Bob Locy Last modified -13F

  2. CSB Fig 02:01 Cell signalling pathways Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  3. Transducers Second Messengers II • Nitric Oxide • cyclic GMP Signaling • Redox signaling • ROS signaling

  4. CSB Fig 2:45 NO and cyclic GMP signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  5. CSB Fig 2:46 NO synthase mechanism Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  6. CSB Fig 2:47 eNOS activation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  7. CSB Fig 2:48 Summary of redox signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  8. CSB Fig 2:49 Reactive oxygen species (ROS) Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  9. CSB Fig 2:50 Sites of ROS formation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  10. CSB Fig 2:51 Plasma membrane ROS formation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  11. CSB Fig 2:52 GSH/GSSG couple Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  12. CSB Fig 2:53 H2O2 metabolism Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  13. CSB Fig 2:54 Peroxiredoxin catalytic cycles Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  14. CSB Fig 2:55 Reversible & irreversible ROS oxidations Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  15. CSB Fig 2:56 ROS formation and action Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  16. CSB Fig 2:57 Recovery of protein oxidation Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  17. CSB Fig 2:58 Thimerosal-induced Ca2+ signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  18. Module 2:59 Figure ROS effects on Ca2+ signalling Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  19. CSB Fig 2:60 ROS microdomains Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

  20. CSB Fig 2:61 ROS microdomains Cell Signalling Biology - Michael J. Berridge - www.cellsignallingbiology.org - 2012

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