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Ethanol. Ethanol Acetaldehyde PEth ROS Others. RTK. GPCR/ G-proteins. Src. Acetaldehyde. Ras-raf. PKC. PEth. ROS , others. MEK 1/2. Acetate. p38 MAPK. p42/44 MAPK. JNK1/2. Caspases. ?. p42/44 MAPK. JNK1/2. p38 MAPK. MSK 1/2. Histone/chromatin modification
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Ethanol Ethanol Acetaldehyde PEth ROS Others RTK GPCR/ G-proteins Src Acetaldehyde Ras-raf PKC PEth ROS , others MEK 1/2 Acetate p38 MAPK p42/44 MAPK JNK1/2 Caspases ? p42/44MAPK JNK1/2 p38 MAPK MSK 1/2 Histone/chromatin modification (acetylation, phosphorylation etc.) Transcription factor/activation (NFkB, AP1, CREB etc.) NUCLEUS Apoptosis Inflammation Proliferation Differentiation