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Drug categories

Drugs that affect neuronal functioning by altering neuronal transmission in ways other than attaching to synaptic receptors. Drug categories. Agonist - A drug that facilitates the effects of a particular neurotransmitter on the postsynaptic cell.

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Drug categories

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  1. Drugs that affect neuronal functioning by altering neuronal transmission in ways other than attaching to synaptic receptors.

  2. Drug categories Agonist - A drug that facilitates the effects of a particular neurotransmitter on the postsynaptic cell Antagonist - A drug that opposes or inhibits the effects of a particular neurotransmitter on the postsynaptic cell

  3. Type of Drug Action • Drug affects the amount of neurotransmitter stored in vesicles • If it facilitates storage (e.g., by acting as a precursor) -agonist • If it inhibits storage (e.g., by inhibiting synthesis of neurotransmitter or by blocking the storage into vesicles) - antagonist • Drug affects release of neurotransmitter • If it increases release - agonist • If it inhibits release -antagonist • Drug affects reuptake/breakdown of neurotransmitter • If it facilitates reuptake/breakdown - antagonist • If it inhibits reuptake/breakdown - agonist

  4. Drug effects on Dopaminergic neurons • Effects on the amount of neurotransmitter stored in vesicles • L-DOPA facilitates synthesis of DA by acting as a precursor -agonist • Deprenyl facilitates synthesis of DA by blocking the enzyme MAO-agonist • Reserpine blocks the storage of DA into vesicles - antagonist • Effects on the release of neurotransmitters • Amphetamine increases release of DA- agonist • Effects on the reuptake of neurotransmitters • Cocaine and amphetamine blocks DA reuptake- agonist

  5. Drug effects on Acetylcholinergic neurons • Effects on the amount of neurotransmitter stored in vesicles • Choline facilitates synthesis of ACh by acting as a precursor -agonist • Effects on the release of neurotransmitters • Botulinum toxin blocks the release of ACh - antagonist • Black widow spider venomfacilitates the release of ACh - agonist • Effects on the breakdown of neurotransmitters • Physostigmine blocks ACh breakdown by inhibiting the enzyme Acetylcholinesterase- agonist

  6. Drug effects on Serotonergic (5-HT) neurons • Effects on the amount of neurotransmitter stored in vesicles • PCPA inhibits synthesis of 5-HT - antagonist • Effects on the release of neurotransmitters • Fenfluraminefacilitates the release of 5-HT - agonist • Effects on the reuptake of neurotransmitters • Fluoxetine (Prozac) blocks reuptake of 5-HT- agonist

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