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Aerobic, Gram negative coccobacillus Alcaligenaceae Family Specific to Humans

Aerobic, Gram negative coccobacillus Alcaligenaceae Family Specific to Humans Colonizes the respiratory tract Whooping Cough (Pertussis). Epidemiologi Penyakit pertusis tersebar di seluruh dunia mudah sekali menular . Manusia satu-satunya sumber Bordetella pertussis,

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Aerobic, Gram negative coccobacillus Alcaligenaceae Family Specific to Humans

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  1. Aerobic, Gram negative coccobacillus Alcaligenaceae Family Specific to Humans Colonizes the respiratory tract Whooping Cough (Pertussis)

  2. EpidemiologiPenyakitpertusistersebar di seluruhdunia mudahsekalimenular. Manusiasatu-satunyasumberBordetella pertussis, Penyebaranpenyakit selaluoleh orang-orang denganinfeksiaktif. Banyakkasuspadaanak-anak di bawah 5 tahun, sebagianbesarmeninggalpadausia 1 tahun.

  3. ManifestasiKlinismasa tunas 7-14 hari. Stadium penyakit1.Stadium kataralis ( 1-2 minggu). Batuk-batukbertambahberatdansiangdanmalam menyerupaiinfuenza.2.Stadium spasmodik (2-4 minggu). terjadiparoksismalberupabatuk-batukkhas. Batukmukamerahdansianotik. Seranganbatukpanjang, tidakadainspiriumdiakhiridengan whoop muntahdanbanyak sputum . terberakdanterkencing-kencing, perdarahansubkonjungtivadanepistaksis 3.Stadium konvalensi(2 minggu) Padaminggukeempatberatnyaseranganberkurang, nafsumakantimbulkembali. Ronkhidifusmulaimenghilang.

  4. PATOGENESE b.pertusis MELEKAT PADA CILIA EPITEL 7-10 DAYS BRONCHUS BROCHIOLUS LPT  LYMPOCYT PROMOTING FACTOR MUKOSA : FOKAL NEKROSIS + SEL RADANG LYMPOCYTOSIS EKSUDAT MUCOPURULEN PERI BRONCHIAL-INTERTITIAL-PNEUMONITIS BATUK ATELEKTASIS BRONCHIECTASIS SUMBATAN JALAN NAFAS

  5. PATOGENESE PERIBRONCHIAL INTERTITIAL PNEUMONITIS EKSUDAT MUCO PURULENT BATUK SPASMODIK SUMBATAN JALAN NAFAS FRENULUM LIDAH ROBEK HYPOKSIA ASPIRASI PNEUMONI ENSELOPATIA DEHIDRASI HERNIA EFEK FALSAVA ATELEKTASIS BRONCHIECTASIS

  6. Komplikasi 1.Alat pernafasanDapatterjadi otitis media (seringpadabayi), bronkitis, bronkopneumonia, atelektasis yang disebabkansumbatanmukus, emfisema , emsifema mediastinum, leher, kulitpadakasus yang berat), bronkiektasis, tuberkulosisdapatmenjadibertambahberat.2.Alat pencernaanMuntah-muntah yang beratmenimbulkanemasiasi, prolapsusrektumatau hernia , ulkuspadaujunglidahkarenalidahtergosokpadagigiatautergigitwaktuseranganbatuk, stomatitis.3.Susunan sarafKejangkarenagangguankeseimbanganelektrolit kongestidan edema otak, mungkin pula terjadiperdarahanotak.4.Lain-lainperdarahanepistaksis, hemoptisisdanperdarahansubkonjungtiva.

  7. Penatalaksanaan1.Antibiotikaa.Eritromisindengandosis 50 mg/kb bb/ haridibagidalam 4 dosis. b.Ampisillindengandosis 100mg/ kg bb/ haridibagi 4 dosis.c.Lain-lain : rovamisin, kotrimoksazol, kloramfenikol, tetrasiklin2.Ekspektoransia danmukolitik3.Kodein diberikanbilaterdapatbatuk-batuk yang hebatsekali4.Luminal sebagaisedativa.

  8. Toxins Pertussis Toxin AdenylateCyclase Toxin Tracheal cytotoxin Dermonecrotic toxin Heat-labile toxin

  9. Adenylate Cyclase Toxin • Invasive toxin • Activated by host cell calmodulin • Impairment of immune effector cells

  10. UPAYA PENCEGAHAN KERENTANAN & KEKEBALAN

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