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Biology 624 - Developmental Genetics

Biology 624 - Developmental Genetics. Lecture #3 - Gametogenesis and Fertilization. Gametogenesis- -the formation of GERM CELLS that will go on to form progeny- 1. Begins during embryogenesis 2. Involves several steps that are independent of sex 3. Continues with sex-specific

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Biology 624 - Developmental Genetics

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  1. Biology 624 - Developmental Genetics Lecture #3 - Gametogenesis and Fertilization

  2. Gametogenesis- -the formation of GERM CELLS that will go on to form progeny- 1. Begins during embryogenesis 2. Involves several steps that are independent of sex 3. Continues with sex-specific processes (ie differ between egg and sperm)

  3. Germ cell competence Germ cell specification Germ cell migration to gonads Oogenesis -results in relatively large gamete with nutritional and informational molecules Spermatogenesis -results in motile gamete with haploid DNA content Sperm-egg contact Sperm-egg fusion Development initiates

  4. Specification of Mammalian PGCs

  5. Segregation of P-granules into the Germ LineLineage of the C. elegans Embryo

  6. Segregation of P-granules into the Germ LineLineage of the C. elegans Embryo

  7. The Pole Plasm of Drosophila

  8. Maternal Effect Genes

  9. Localization of Germ Cell-Less Gene Products in the Posterior of the Egg and Embryo

  10. Inhibition of Transcription in Germ Cell Precursors of C. elegans

  11. Inhibition of Transcription at Ectopic Sites in Drosophila by germ cells-less GCL Hoechst H5 staining WT WT + GCL Leatherman et al (2002) Curr Biol 12, 1681-1685

  12. Pathway for the Migration of Mammalian Primordial Germ Cells

  13. Pathway for the Migration of Mammalian Primordial Germ Cells

  14. The Modification of a Germ Cell to Form a Mammalian Sperm

  15. The Ovarian Follicle of Mammals

  16. The Formation of 16 Interconnected Cystocytes in Drosophila

  17. In Amphibian Oocytes, Lampbrush Chromosomes are Active During First Meiotic Prophase

  18. The Formation of 16 Interconnected Cystocytes in Drosophila

  19. Specifying the Anterior-Posterior Axis of the Drosophila Embryo During Oogenesis

  20. Specifying the Anterior-Posterior Axis of the Drosophila Embryo During Oogenesis

  21. Formation of the Anterior-Posterior Axis of the Drosophila Embryo

  22. Events Leading to the Fusion of Egg and Sperm Plasma Membranes

  23. Wave of Calcium Release across Sea Urchin Eggs During Fertilization

  24. Possible Mechanisms of Egg Activation

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