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Developmental Genetics

Developmental Genetics. Three Stages of Development. division morphogenesis differentiation. What leads to changes?. Differential gene expression. Caused by. Sequential Regulation. Gene Expression is sequentially regulated Cells become determined before they differentiate.

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Developmental Genetics

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  1. Developmental Genetics

  2. Three Stages of Development • division • morphogenesis • differentiation

  3. What leads to changes? • Differential gene expression. • Caused by...

  4. Sequential Regulation • Gene Expression is sequentially regulated • Cells become determined before they differentiate

  5. Plants have totipotent stem cells (meristems) throughout life Animals have totipotent stem cells for short part of life Animal cells move in development Plant and animal devo

  6. Of course we have videos • Human Development • Different types of potential cells • Embryonic stem cell lines • Nuclear transfer: cloning

  7. Cloning • Reproductive cloning • Many problems • Defects • Too many methyl groups

  8. Stem Cells • Adult stem cells • Bone marrow • Brain • Skin • Hair • Eyes • Dental pulp • Embryonic stem cells are pluripotent • Therapeutic cloning • New induced pluripotent stem cells from adult cells.

  9. Pattern Formation in Animals • Establishes major axes: • Anterior posterior • Right and left sides • Video

  10. Homeotic Genes • Homeotic genes contain homeobox sequences (180 nucleotides long) regulate body part formation • Homeobox codes for homeodomain (60 aa long) • Homeodomains are almost identical in animal kingdom • A video…of course

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