1 / 6

Testing the antidepressant efficacy of P2X7 antagonist in M. bovis , BCG challenged mice.

Testing the antidepressant efficacy of P2X7 antagonist in M. bovis , BCG challenged mice. Jason O’COnnor. Sucrose Preference Test. *. Significant two way interaction, only a significant BCG effect observed in control group. No other groups are significantly different from each other.

dylan-potter
Download Presentation

Testing the antidepressant efficacy of P2X7 antagonist in M. bovis , BCG challenged mice.

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Testing the antidepressant efficacy of P2X7 antagonist in M. bovis, BCG challenged mice. Jason O’COnnor

  2. Sucrose Preference Test * Significant two way interaction, only a significant BCG effect observed in control group. No other groups are significantly different from each other.

  3. Open Field Test Locomotor activity Anxiety-like behavior No difference in locomotor activity between groups. A significant main effect of BCG in duration of time spent in central area (anxiety-like phenotype)

  4. Social Interaction Test No significant two way interaction (p=0.1), only a significant BCG effect observed in control group. *

  5. Y-maze Spontaneous Alternation Significant two way interaction, only a significant BCG effect observed in control group. No other groups are significantly different from each other. *

  6. Tissues collected • Plasma • At the end of behavioral study • In a small parallel group of mice at 8d post BCG • Brains (cortical hemispheres and cerebellum) • At the end of behavioral study • In a small parallel group of mice at 8d post BCG • Lung • At the end of behavioral study • In a small parallel group of mice at 8d post BCG

More Related