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NCI Mean GI 50 graph for NSC 721648, GW 610 (ii)

Fig 1. NCI Mean GI 50 graph for NSC 721648, GW 610 (ii). Lung. Colon. Renal Breast. Induction of CYP1A1 mRNA by 5F 203 and GW 610. Fig 2. Fig 3. Resveratrol Incubations. Resveratrol is an inhibitor of CYP1A1 and CYP1B1. HCC 2998 with DF203 or GW610 ± 5uM Resveratrol.

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NCI Mean GI 50 graph for NSC 721648, GW 610 (ii)

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  1. Fig 1 NCI Mean GI 50 graph for NSC 721648, GW 610 (ii) Lung Colon Renal Breast

  2. Induction of CYP1A1 mRNA by 5F 203 and GW 610. Fig 2

  3. Fig 3 Resveratrol Incubations • Resveratrol is an inhibitor of CYP1A1 and CYP1B1 HCC 2998 with DF203 or GW610 ± 5uM Resveratrol MCF-7 with DF203 or GW610 ± 5uM Resveratrol HCC 2998 remains sensitive to both DF203 and GW610 even after resveratrol treatment, showing CYP1A1 is not involved in activating either drug in this cell line Resveratrol reduces the potency of DF203 but not GW610 in MCF-7 cells, showing CYP1A1 is essential in the activity of DF203 but not GW610

  4. Fig 4 Inhibition of CYP1A1 activity by GW 610

  5. Induction of CYP1B1 mRNA by 5F 203 and GW 610 Fig 5

  6. Fig 6 1809.38 Adducts/108 Nucleotides MCF-7 10uM GW610 2628.62 Adducts/108 Nucleotides MDA 468 10uM GW610 677.90 Adducts/108 Nucleotides KM12 10uM GW610 1961.90 Adducts/108 Nucleotides HCC 2998 10uM GW610

  7. Fig 7 6068.09 Adducts/108 Nucleotides MCF-7 10uM 4F610 1627.65 Adducts/108 Nucleotides MDA 468 10uM 4F610 956.10 Adducts/108 Nucleotides KM12 10uM 4F610 216.54 Adducts/108 Nucleotides HCC 2998 10uM 4F610

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