Investigation: Molecules to Man (and back)

1. Investigation: Molecules to Man (and back) Robert P. Kimberly, M.D. Howard Holly Professor of Medicine Senior Associate Dean for Research Director, UAB Arthritis and Musculoskeletal Center

2. Investigation: M2M and back • How to establish a career Identify a mentor, and have a coffee at least once a month Organize your lab, and don’t hesitate to use the HHMI website Understand the expectations for promotion Research productivity Teaching performance Service (resource, admin, clinical)

3. Investigation: Identify a mentor • Lucy's Coffee & Tea2007 University Blvd.328-2007In addition to coffee and tea, Lucy's offers sandwiches, salads, baked goods and more at good prices. Warm, friendly atmosphere, retro furniture and funky artwork. City Scene gave high marks to the smoked turkey sandwich, with smoked gouda, tomato chutney and arugula, served on toasted ciabatta bread from Edgar's Bakery.

4. Investigation: Organize your lab • HHMI “Making the Right Moves, A Practical Guide to Scientific Management for Postdocs and New Faculty” (http://www.hhmi.org/grants/pdf/labmgmt/book.pdf) • Staffing your lab • Mentoring • Getting funded • Project and data management • Setting up collaborations • Publications • Technology transfer

5. Investigation: Organize your lab • Occupational Health & Safety - radiation safety, chemical safety, etc. (http://www.healthsafe.uab.edu/pages/educationandtraining/educationandtraining.html) • Use of Animal Subjects – general information and species specific training (http://main.uab.edu/internal/show.asp?durki=34597) • Use of Human Subjects – initial training and continuing education(http://main.uab.edu/show.asp?durki=58146) • Effort Reporting (https://courses.uab.edu/)

6. Investigation: Organize your lab • Mandatory certifications • UAB Code of Conduct • (http://www.hrm.uab.edu/codeofconduct) • HIPAA • (http://www.hipaa.uab.edu/training.htm)

7. Investigations: Organize your lab

8. http://main.uab.edu/research • Administration and Oversight • Animal Resources Program (ARP) • Clinical Trials • Conflict of Interest Review Board • Grants and Contracts Accounting • Institutional Animal Care & Use Committee (IACUC) • Institutional Review Board (IRB) for Human Use • Occupational Health & Safety • Office of Grants and Contracts Administration (OGCA) • Office of Research Compliance • Office of Sponsored International Programs (OSIP) • Research Foundation (UABRF) • University Counsel Office

9. http://main.uab.edu/research • Facilities • Alabama Department of Public Health (ADPH) • Birmingham Regional Emergency Medical Services System (BREMSS) • Birmingham Veterans Affairs Medical Center (BVAMC) • Centers at UAB including those based in departments and schools • Jefferson County Department of Health (JCDH) • Pittman General Clinical Research Center GCRC • Southeast Biosafety Laboratory Alabama Birmingham (SEBLAB) • Southern Research Institute • UAB Clinical Facilities

10. http://main.uab.edu/research • Forms • Animal Resources Program(ARP) Forms • Conflict of Interest Review Board (CIRB) Forms • Grants and Contracts Accounting Forms • Institutional Animal Care and Use Committee (IACUC) Forms • Institutional Review Board for Human Use (IRB) Forms • Occupational Health and Safety (OHS) Forms • Office of Grants and Contracts Administration (OGCA) Forms • UAB Research Foundation (UABRF) Forms

11. http://main.uab.edu/research • Graduate and Postdoctoral Training • International Research Training Programs • Office of Postdoctoral Education • The Graduate School • Technology Transfer and Economic Development • Office for the Advancement of Developing Industries (OADI) • UAB Research Foundation • UAB Research Park at Oxmoor

12. http://main.uab.edu/research • Regulatory Training • Check courses taken • Effort Reporting • HIPAA • Institutional Animal Care and Use Committee Training (IACUC) • Occupational Health and Safety (OHS) • Office of Institutional Review Board for Human Use (IRB)

13. http://www.uab.edu/uasom/research/ UAB core facilities Budget and grant writing links Mentoring resources Funding opportunities Compliance

14. Investigation: Expectations Research Productivity: How to choose an area for investigation Think broadly – the NIH Roadmap Look at UAB UWIRC Centers Look for translational opportunities

15. Investigation: Expectations • Government Resources (www.grants.gov) • Federal • State • Private Resources • Foundations and Associations • Nonprofit Centers • Charities • Internal Funding – University Sponsored Research Productivity: Funding

16. Investigation: Expectations • NIH resources for new investigators • http://grants.nih.gov/grants/new_investigators/resources.htm • Identify appropriate individual NIH career awards by using the wizard • http://grants.nih.gov/training/kwizard • All about grants tutorials • http://www.niaid.nih.gov/ncn/grants/default.htm • Annotated grant • Annotated summary statement

17. NIH Small Grant Program (R21) • New, exploratory and developmental research projects • Supports early stages of project development • May involve considerable risk but may lead to a breakthrough in a particular area, or to the development of novel techniques, agents, methodologies, models or applications that could have major impact on a field of biomedical, behavioral, or clinical research • Should break new ground or extend previous discoveries toward new directions or applications

18. Associations & Foundations • American Heart Association • American Lung Association • American Cancer Society • Arthritis Foundation • Howard Hughes Medical Institute • National Marfan Foundation • Ellison Medical Foundation • Cystic Fibrosis Foundation • The Alzheimer’s Association • FRAXA Research American Heart Foundation • American Diabetes Foundation • Leukemia and Lymphoma Society. • Juvenile Diabetes Research Foundation • National Neurofibromatosis Foundation • Coulter Foundation

19. UAB Nominates Candidates: • Ellison Medical Foundation (Aging) • The John Merck Fund (Developmental Disabilities in Children) • The W. M. Keck Foundation's Distinguished Young Scholars in Medical Research • Pew Scholars Program • Burroughs Wellcome Biomedical Scholars • Howard Hughes • Daymon Runyon Foundation • Searle Scholars

20. Investigation: updates on funding • Join the UABRADM listserve • (http://www.uab.edu/uabra/uabradm_request.htm) • Join the Community of Science - keep your biosketch updated! • (www.cos.com) • Subscribe to the NIH NEXUS Listserve • (http://grants.nih.gov/grants/nexus.htm) • Search • (www.grants.gov) • Talk to your colleagues

21. The “Independent” Investigator • Publishes in high quality journals in a given area • Serves as a principal investigator of grants or contracts • Significant and sustained extramural funding • Supervises graduate students, post doctoral and clinical fellows • Initiates and participates in research collaborations

22. Investigation: M2M and back • How to establish a career Identify a mentor, and have a coffee at least once a month Organize your lab, and don’t hesitate to use the HHMI website Understand the expectations for promotion Research productivity Teaching performance Service (resource, admin, clinical)

23. Investigation: Expectations

24. Investigation: Expectations

25. Investigation: Expectations

26. CTSA: Additional Considerations • NCRR K12, K30, M01 and Roadmap T32 and K12 awards will be reconfigured into the CTSA program • Non-NCRR and Roadmap NIH categorical awards will not be included in the reconfiguration • It is anticipated that they will benefit from the CTSA infrastructures • CTSA will be expected to complement and interact with existing centers that are funded by the categorical institutes of the NIH

28. CTSA: Additional Considerations CTSA Key Components • 1. Development of Novel Clinical and Translational Methodologies • 2. Pilot and Collaborative Translational and Clinical Studies • 3. Biomedical Informatics • 4. Design, Biostatistics, and Clinical Ethics • 5. Regulatory Knowledge and Support • 6. Participant and Clinical Interactions Resources • 7. Community Engagement • 8. Translational Technologies and Resources • 9. Research Education, Training and Career Development • 10.Self-Monitoring and Improvement Program

30. The Clinical and Translational Science Award (CTSA): platform for leveraging the MCRC mission Robert P. Kimberly, M.D. Principal Investigator, UAB MCRC September, 2006

32. Priority Research Themes and Enabling Platforms Priority Research Themes Cancer Cardio- vascular Biology Diabetes, Obesity, and Metabolic Diseases Immunology, Autoimmunity & Trans-plantation Infectious Diseases & Vaccines Neuro- sciences • Key (mission-critical) requirements and transforming factors for future productivity, accelerated growth, and • resource investments • Expand leadership and faculty • Increase technological innovation and research capacity • Promote research training and education • Manage resources responsibly and effectively • Align SOM mission and research planning with the UAB Health System Fundamental Research Molecule Faculty, research technologies, methodologic resources, space, and collaboration/coordination Enabling Platforms Individual Clinical Research : spans prospective, randomized, clinical trials to population-based studies Population Care Delivery and Disease Prevention (UAB Health System)

33. Five Key Recommendation Areas A) Recruit, retain, and maintain leadership and faculty expertise. B) Develop, re-engineer, and improve enabling platforms, technological innovation, and research capacity. C) Enhance current and develop new paradigms for graduate/post graduate education and training, creating integration and flexibility that allows recruitment of the best and brightest future scientists. D) Enhance organizational stewardship and effectiveness. E) Reduce administrative barriers for conducting research.

34. Leadership and Faculty Recruitment • Complete ongoing leadership recruitments for The Comprehensive Cancer Center, The Comprehensive Diabetes Center, The Heflin Genetics Center, and fundamental immunology • Initiate recruitment efforts for new group leaders for bioinformatics, cardiovascular biology, medical informatics, vaccinology, and experimental imaging • Aggressively recruit 30 research faculty per year over the next 5-7 years, with the expectation that half of those recruited will be funded at the time of appointment. Recruitment should be focused on investigators in basic sciences, translational investigation and outcomes and disparities research. • Create a Comprehensive Neurosciences Center and recruit or identify a Director. • Enhance cooperative recruiting efforts and coordinate investments with other Schools at UAB and with Southern Research Institute.

35. Enabling Platforms, Technological Innovation, and Research Capacity • Enhance the currently available imaging technology dedicated to research on humans, experimental animals, and live cell/tissue specimens by expanding capacity of existing technologies, acquiring of new technologies and recruiting academic experts in selected imaging modalities. • Enhance model organism capacities, including genetically engineered mice and other systems, to complement cellular, molecular, and behavioral studies. • Develop research capabilities in medical informatics. • Facilitate translational initiatives by increasing the service capabilities in genomics and proteomics, bioinformatics, study design, outcomes, biostatistics and innovative study techniques, and drug discovery. • Coordinate and consolidate research core management, expand core capabilities and develop an on-going process for needs assessment and innovation. Investigate opportunities for collaborative cores involving other universities, Southern Research Institute and other partners.

36. Education and Training Opportunities • Establish a single administrative structure for graduate programs in the biomedical sciences that will also provide administrative support for T32 and other training/fellowship grant applications. • Create new interdepartmental, interdisciplinary training programs that will serve as magnets for recruitment and foci for faculty involvement. • Develop synergies between the graduate and medical curricula and create PhD and other advanced degree opportunities at the medical postgraduate level. • Develop a more competitive national position through more effective recruitment, appropriate stipends, and expansion of graduate programs commensurate with the increase in faculty. • Increase institutional resources for graduate stipends/tuition costs to provide complete support for the first 18-24 months of the graduate student curriculum. • Establish infrastructure support for clinical research trainees through support of faculty mentoring and space for clinical research training activities, in alignment with other translational science initiatives.

37. Organizational Stewardship and Effectiveness 17. Establish mechanisms to recognize the continuing leadership and research contributions of our most productive faculty, including endowed chairs and other support avenues. 18. Expand the development office to secure more endowments, gifts, and unrestricted funds from the philanthropic community. Efforts should be made to assure that donors interested in specific diseases are made aware of first-rate basic scientists as well as clinicians. 19. Promote ongoing faculty productivity and development through bridge funding mechanisms and by providing opportunities for re-tooling of academic and research skills, including internal and external sabbaticals and pilot funding in targeted research areas. 20. Formalize a process to annually review faculty accomplishments and to identify and nominate “marquee” faculty for national distinction (i.e., NAS, IOM, HHMI, etc.). 21. Recognize and promote/reward non-tenure track faculty who lead research service cores.

38. Organizational Stewardship and Effectiveness (continued) 22. Enhance organizational efficiency and effectiveness by streamlining operational redundancies in administrative and departmental structures, implementing regular five year reviews of departments, and examining tenure and compensation policies. 23. Facilitate a more effective relationship with the VA. 24. Create a joint strategic planning office involving the UAB Health System, HSF, and the SOM to promote and reinforce alignment between the SOM and the clinical enterprise. In parallel, promote similar efforts with Children’s Hospital.

39. Overcoming Administrative Barriers 25. Help define accountability (including from the perspective of user groups) of all central administrative units that support the research mission. This must include expectations of competence, efficiency, and a customer-service-oriented approach to dealing with constituents. 26. Assure that all training requirements for researchers are well thought out and available via media that provide efficacious and efficient compliance. 27. Develop procedures for the timely negotiating of contracts, CDAs, and MTAs that allow UAB investigators to compete at a level comparable to peers at other institutions. 28. Enable clinical research through the continued development of the Office of Human Research and the implementation of research-enabling support software. 29. Assure that electronic grant submission mechanisms are in place and user-friendly. 30. Facilitate intra- and inter-institutional as well as international collaborations by establishing a searchable database of faculty expertise and research interests and establishing an International Research Support Office.

40. Strategic Planning Implementation Committee

41. SOM Research Strategic Plan “Good thoughts are no better than good dreams unless they be executed.” Ralph Waldo Emerson Just do it

44. The UAB SOM Strategic Plan:transition from planning to operations Robert P. Kimberly, M.D. Senior Associate Dean for Research June 15, 2006