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Master Thesis Colloquium 18-2-2011

A preliminary study to improve the mammographic breast cancer screening with the implementation of a local pressure sensing system. Master Thesis Colloquium 18-2-2011. Introduction. Breast cancer. Most common cancer in women 1 out 8 women get any form of breast cancer

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Master Thesis Colloquium 18-2-2011

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  1. A preliminary study to improve the mammographic breast cancer screening with the implementation of a local pressure sensing system Master Thesis Colloquium 18-2-2011

  2. Introduction • Breast cancer • Most common cancer in women • 1 out 8 women get any form of breast cancer • 15% of all cancer deaths caused by breast cancer • Fairly treatable disease when detected early

  3. Introduction • Mammography Breast cancer detection Screening (mammography) Diagnosing

  4. Introduction • Mammography

  5. Introduction • Mammography X-ray CC X-ray MLO

  6. Introduction • Mammography

  7. Objective • Title A preliminary study to improve mammographic breast cancer screeningwith the implementation of a local pressure sensing system. A preliminary study to improve mammographic breast cancer screening with the implementation of a local pressure sensing system. • Same protocol as used in standard mammography • No additional time and operation • Same compression A preliminary study to improve mammographic breast cancer screening with the implementation of a local pressure sensing system.

  8. Objective • Pre-menopausal breast Fat Mammary gland Cooper’s ligaments Elasticity fat converges to elasticity glandular tissue in large deformations [1] [1] Azaret al.

  9. Objective • Post-menopausal breast Fat Healthy breast tissue Mammary gland Cooper’s ligaments Glandular tissue atrophies

  10. Objective • Cancerous breast • Tumor • Spherical shape • Higher stiffness (8-20 times)

  11. Objective • Problem description Simplification of the problem: Geometry Physiology 30 mm Breast containing a tumor Cylinder containing an inclusion

  12. Contents • Contents

  13. Contents • Contents

  14. Contents • Contents

  15. Theoretical study • Finite Element Analysis Th R P

  16. Theoretical study • Finite Element Analysis Input parameters: Relative elasticity (Ehealtytissue : Etumor ) Depth (P) Radius (R) Relative elasticity (E1/E2) Depth (P)

  17. Theoretical study • Finite Element Analysis Input parameters: Relative elasticity (Ehealtytissue : Etumor ) Depth (P) Radius (R) Relative elasticity (E1/E2) Depth (P)

  18. Theoretical study • Results Peak value Relative stress Depression Footprint (L) 0 -1 1

  19. Theoretical study • Peak value Peak Peak Relative elasticity (E1/E2) Relative depth (P/R) Peak value E2 E1 P 2R

  20. Theoretical study • Footprint Footprint (D/L) Footprint (D/L) Relative depth (P/R) Relative elasticity (E1/E2) E2 E1 2R P Footprint (L)

  21. Contents • Contents

  22. Experimental study • Setup Tensile tester Line-array pressure sensors Silicone tissue phantom

  23. Experimental study • Setup Tensile tester Line-array pressure sensors Silicone tissue phantom

  24. Experimental study • Setup Tensile tester Line-array pressure sensors Silicone tissue phantom

  25. Experimental study • Setup

  26. Experimental study • Problems during experimental study Lubrication layer to overcome shear stresses at the surface

  27. Experimental study • Results Relative stress X (mm)

  28. Experimental study • Results Relative stress X (mm)

  29. Experimental study • Results Relative stress X (mm)

  30. Experimental study • results 12mm inclusion Relative stress X (mm)

  31. Contents • Contents

  32. Conclusions • Conclusions Theoretical study • A peak is found in vertical stress distribution around an inclusion • Relative depth (P/R)  Does influence the stress distribution • Relative elasticity (E1 / E2 )  Does not influence the stress distribution Experimental study • Inclusions smaller than 10 mm are not detected in the experimental study • Implementation in standard mammography is possible • Radio lucent pressure sensors • Filtering of shear stresses along surface Objective: Feasibility of implementing local pressure sensors in standard mammographic devices Promising feature to detect tumors

  33. Conclusions • Where will this lead to..

  34. Contents • Contents

  35. Recommendations • Theoretical study • Better geometry of the breast • Extending material properties: • Absolute elastic behavior • Viscoelastic behavior • Analytical definition of stress behavior around inclusion • validate finite element analysis.

  36. Recommendations • Experimental study • Improving pressure sensing system • Radio-lucent pressure sensing system • 2-dimensional instead of 1-dimensional • Higher accuracy of the sensors • Higher resolutions of the sensors

  37. THANK YOU FOR YOUR ATTENTION!

  38. Experimental Study • results

  39. Single sensor setup Single sensor circuit

  40. Objective • Analytical problem

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