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ECCR Overview/MLSCN

ECCR Overview/MLSCN. NIH Roadmap. Series of initiatives designed to pursue major opportunities in biomedical research and gaps in current knowledge that cannot be addressed by any single NIH Institute or Center

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ECCR Overview/MLSCN

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  1. ECCR Overview/MLSCN

  2. NIH Roadmap • Series of initiatives designed to pursue major opportunities in biomedical research and gaps in current knowledge that cannot be addressed by any single NIH Institute or Center • Goal: enable rapid transformation of new scientific knowledge into tangible benefits for public health • http://nihroadmap.nih.gov/

  3. NIH Roadmap Molecular Libraries Initiative (MLI) • A series of integrated research programs with the goal of making small molecule screening and screening data more widely available to the research community • http://nihroadmap.nih.gov/molecularlibraries/index.asp

  4. MLI Aims • Go beyond the identification of compounds with potential therapeutic properties • Identify compounds to use as probes to study cellular processes in health and disease • Biological screening data, assay protocols, and chemical structures for compounds to be publicly available in PubChem

  5. NIH MLI Components • Molecular Libraries Screening Center Network (MLSCN) • Cheminformatics (centered around PubChem) • Technology development

  6. Roadmap MLI Funded Areas • Exploratory Centers for Cheminformatics Research at: • Indiana University • University of Michigan • Rensselaer Polytechnic Institute • MIT • North Carolina State University, Raleigh • University of North Carolina, Chapel Hill

  7. NIH MLI Technology Development Areas • Chemical diversity • Pilot-scale libraries for investigation of novel chemical diversity space • Novel methods for natural product chemistry • Development of assays • Novel instrumentation and detection technologies for high throughput screening • Datasets and algorithms for better prediction of absorption, distribution, metabolism, excretion, and toxicity properties of small molecules

  8. Roadmap MLI Funded Areas • Molecular Libraries Screening Centers (MLSCN) • Ten of them at academic institutions • NIH Chemical Genomics Center • http://www.ncgc.nih.gov/ • http://nihroadmap.nih.gov/molecularlibraries/fundedresearch.asp

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