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Function Express. November 30, 2007. Compute Nodes. Function Express: Architecture. MGA. MAC. LocalDB (MySQL). Chip Data Virtual Experiment Data. Integrated DB (Oracle 9i). Individual. Chip Data Gene Annotations Analysis. LocalDB (MySQL). Bioinformatics Core. Laboratory.
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Function Express November 30, 2007
Compute Nodes Function Express: Architecture MGA MAC LocalDB (MySQL) Chip Data Virtual Experiment Data Integrated DB (Oracle 9i) Individual Chip Data Gene Annotations Analysis LocalDB (MySQL) Bioinformatics Core Laboratory
Function Express: Viewers Clinical Data Category History Probeset Data Probeset Comments Category Comments
SAM PCA Weighted Voting
Function Express: Analyzing Data • SVM • Consensus Clustering • Comparative Marker Selection
Function Express: What to do after analysis? • Are co-expressed genes co-regulated? • What regulatory networks are operating/perturbed in your experimental paradigm? • What pathways/processes emerge from a set of ‘interesting’ genes? • Promoter Analysis Pipeline • Gene Network Viewer • IPA
Promoter Analysis Pipeline
Gene Network Viewer
Promoter Pipeline Gary Stormo On-site Personnel Li-Wei Chang Hrishikesh Deshmukh Burr Fontaine Caerie Houchins George Joseph Sunita Koul Rekha Meyer Mukesh Sharma Joanne Zhao Software Project Manager Srikanth Adiga Off-shore Personnel Anuj Tiwari Jaydeep Chovatia Rahul Jain Madhumita Shrikande Madhurima Bhattacharjee Ashwini Patil Acknowledgments