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Shikimic acid is present is most plants but in low concentrations

U.S. Patent and Trade Office, Provisional patent application no. 60/841,643 filed August 30, 2006, “ Method of Isolating Shikimic Acid from a Plant ” Inventor: K.A. Anderson. Shikimic acid is present is most plants but in low concentrations

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Shikimic acid is present is most plants but in low concentrations

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  1. U.S. Patent and Trade Office, Provisional patent application no. 60/841,643 filed August 30, 2006, “Method of Isolating Shikimic Acid from a Plant” Inventor: K.A. Anderson. • Shikimic acid is present is most plants but in low concentrations • Shikimic acid is naturally concentrated in chinese star anise seeds • Star anise is used in the pharmaceutical industry as a base material for production of Tamiflu (oseltamivir). Science Supporting Society

  2. U.S. Patent and Trade Office, Provisional patent application no. 60/841,643 filed August 30, 2006, “Method of Isolating Shikimic Acid from a Plant” • Star anise seed as a base material for production of Tamiflu • About 15 to 40 grams of star anise is needed to produce 10 tamiflu vaccines • Only 1 crop per year can be grown in China only • 10 step manufacturing process • Low isolation and yield of shikimic acid from star anise seed blamed for 2005 shortage of tamiflu • 90% of harvest is used by Roche to make Tamiflu • According to Roche major bottle neck to Tamilfu production is availability of shikimic acid Science Supporting Society

  3. “Method of Isolating Shikimic Acid from a Plant-Bio-enhanced Synthesis for Preparation of Shikimic Acid” • Round-up interupts shikimic acid pathway in plants • Results in build-up (high concentration) of shikimic acid in plants • Very fast response • Very large increase Science Supporting Society

  4. “Bio-enhanced Synthesis for Preparation of Shikimic Acid” • Apply Round-up modest amount so plant continues to grow further simplifing harvest • Multiple crops could be grown per year if needed • Simple extraction of plant material • High yield of shikimic acid from plant Science Supporting Society

  5. “Method of Isolating Shikimic Acid From a Plant” • 60 grams of alfafa would produce enough shikimic acid for 10 Tamiflu vacines • Per acre seeds versus alfafa shikimic acid production potential is large • Analytical clean easier • Water extraction of plant • Prepatory chromatography clean-up/isolation Science Supporting Society

  6. U.S. Patent and Trade Office, Provisional patent application no. 60/841,643 filed August 30, 2006, “Method of Isolating Shikimic Acid from a Plant” Inventor: K.A. Anderson. • Outlook ?? • US approved purchase of 25 million doses of Tamiflu • US wants to stock pile >30 million doses • Requires 8.4 million grams of shikimic acid • In 2005 10 g of shikimic acid cost $5 • 8.4 million grams = >$4,000,000.00 • SE Asian estimates: 2.9 BILLION vacines are needed • Other vacines for bird flu • Other sources of shikimic acid • Other methods to produce Tamilfu without using shikimc acid Science Supporting Society

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