Aberrant Wnt / b -catenin signaling can induce
Aberrant Wnt / b -catenin signaling can induce. chromosomal instability in colon cancer. Behrens. J et al , PNAS, 2006. Introduction. ◦ The hallmarks of colon tumors. - APC mutation. Mutations in APC are the most frequent events in colon tumors. (Powell, S.M et al , Nature , 1992).
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