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Cocaine, Amphetamines, Caffeine, Nicotine. Tintinalli Chapter 168. Cocaine. Absorbed from all mucosal surfaces Local anesthetic and CNS stimulant Symptoms Mydriasis Tachycardia, HTN Diaphoresis Euphoria. Amphetamines. Routes Ingestion IV Inhalation Insufflation Popular Drugs
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Cocaine, Amphetamines, Caffeine, Nicotine Tintinalli Chapter 168
Cocaine • Absorbed from all mucosal surfaces • Local anesthetic and CNS stimulant • Symptoms • Mydriasis • Tachycardia, HTN • Diaphoresis • Euphoria
Amphetamines • Routes • Ingestion • IV • Inhalation • Insufflation • Popular Drugs • Ritalin • Action • Enhance release and block reuptake of catecholamines
Cardiac Dysrhythmias Myocarditis, cardiomyopathies MI CNS Seizures Infarctions / bleeds Focal vasospasm Pulmonary More common with crack cocaine Pulmonary edema GI Mesenteric vasospasm Body packing Renal Rhabdomyolysis Clinical Features
Treatment • ABC • Charcoal • Sedation • Tachycardia – benzos • No haldol, droperidol • Seizures • Chest pain in association • No Beta adrenergic antagonists Sir, after reviewing your tests, I know why you are having chest pain. You are ALLERGIC TO COCAINE. Have a nice day – go home.
Caffeine • Similar to theophylline • Routes • IV, IM, SC, PR • Clinical • Enhances cognitive and motor abilities (low dose) • Overdose ~1gram • GI symptoms • tachycardia, agitation