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Dr. Aparna Joshi Chief Medical Officer, Optra Systems (optrasystems)

Automated Toxicology Screening System using Artificial Intelligence based Self Learning Imaging System with Pattern Identification. Dr. Aparna Joshi Chief Medical Officer, Optra Systems (www.optrasystems.com). WHY?. Screening Strategies for Histopathological evaluation in Toxicology -

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Dr. Aparna Joshi Chief Medical Officer, Optra Systems (optrasystems)

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  1. Automated Toxicology Screening System using Artificial Intelligence based Self Learning Imaging System with Pattern Identification Dr. Aparna Joshi Chief Medical Officer, Optra Systems (www.optrasystems.com)

  2. WHY? Screening Strategies for Histopathological evaluation in Toxicology - One of the major problems facing the research industry

  3. Automated Toxicology Screening System • Design based on histological morphology of various tissues • In accordance with pathological lesions • To flag abnormal patterns in high throughput scenario • To “Learn on the Fly” without programmatic changes • To dynamically adapt to various boundary conditions • Personalizable and Customizable • Acceptability on variety of image acquisition devices • Can qualify images as Accept / Reject prior to screening • “An artificial intelligence based self learning imaging system”

  4. OptraAssays™(Image analysis libraries for histopathology in toxicological analysis) • Angiogenesis.dll • Hemorrhage.dll • Pan_Morphometry.dll • Cellularity assessment.dll • Necrosis.dll • Infarction.dll • Fibrosis.dll • Mitoses.dll • Micrometastasis.dll • Adenomyosis.dll

  5. Subcutaneous implantation of a cotton thread in the dorsum of rabbits (Oryctolagus cuniculus ) induced granulation tissue formation with angiogenesis. Automated detection of same. Pre Image Analysis Post Image Analysis Red blood cells Intravascular lumen Endothelial cells

  6. Subcutaneous implantation of a cotton thread in the dorsum of rabbits (Oryctolagus cuniculus ) induced granulation tissue formation with angiogenesis. Automated detection of same. Pre Image Analysis Post Image Analysis Red blood cells Intravascular lumen Endothelial cells

  7. OptraAssays™(Image analysis libraries for histopathology in toxicological analysis) • Angiogenesis.dll • Hemorrhage.dll • Pan_Morphometry.dll • Cellularity assessment.dll • Necrosis.dll • Infarction.dll • Fibrosis.dll • Mitoses.dll • Micrometastasis.dll • Adenomyosis.dll

  8. Automated detection of intratumoral hemorrhage in neuroblastoma Pre Image Analysis Post Image Analysis

  9. Automated detection of intratumoral hemorrhage in neuroblastoma Pre Image Analysis Post Image Analysis

  10. OptraAssays™(Image analysis libraries for histopathology in toxicological analysis) • Angiogenesis.dll • Hemorrhage.dll • Pan_Morphometry.dll • Cellularity assessment.dll • Necrosis.dll • Infarction.dll • Fibrosis.dll • Mitoses.dll • Micrometastasis.dll • Adenomyosis.dll

  11. Automated Morphometry of Pancreatic Islet cells Pre Image Analysis Post Image Analysis

  12. Automated Morphometry of Pancreatic Islet cells Pre Image Analysis Post Image Analysis Cellularity: Normocellular Area/Size : Normal Fibrosis: Absent

  13. Automated Thyroid Histopathology Pre Image Analysis Post Image Analysis Lymphocytes vs Epithelial Cells Colloid Follicular Epithelial Cells

  14. Automated Thyroid Histopathology Pre Image Analysis Post Image Analysis Lymphocytes vs Epithelial Cells Colloid Follicular Epithelial Cells

  15. OptraAssays™(Image analysis libraries for histopathology in toxicological analysis) • Angiogenesis.dll • Hemorrhage.dll • Pan_Morphometry.dll • Cellularity assessment.dll • Necrosis.dll • Infarction.dll • Fibrosis.dll • Mitoses.dll • Micrometastasis.dll • Adenomyosis.dll

  16. Automated detection of Necrosis Pre Image Analysis Post Image Analysis

  17. Automated detection of Necrosis Pre Image Analysis Post Image Analysis

  18. OptraAssays™(Image analysis libraries for histopathology in toxicological analysis) • Angiogenesis.dll • Hemorrhage.dll • Pan_Morphometry.dll • Cellularity assessment.dll • Necrosis.dll • Adenomyosis.dll • Infarction.dll • Fibrosis.dll • Mitoses.dll • Micrometastasis.dll

  19. Female rhesus monkeys (Macaca mulatta) were ovariectomized and treated with subcutaneous implants, each containing 200 mg estradiol. Adenomyosis at necropsyAutomated detection of Adenomyosis Pre Image Analysis Post Image Analysis

  20. Female rhesus monkeys (Macaca mulatta) were ovariectomized and treated with subcutaneous implants, each containing 200 mg estradiol. Adenomyosis at necropsy Automated detection of Adenomyosis Pre Image Analysis Post Image Analysis

  21. OptraAssays™(Image analysis libraries for histopathology in toxicological analysis) • Angiogenesis.dll • Hemorrhage.dll • Pan_Morphometry.dll • Cellularity assessment.dll • Necrosis.dll • Adenomyosis.dll • Infarction.dll • Fibrosis.dll • Mitoses.dll • Micrometastasis.dll

  22. Summary OptraAssays™ • Angiogenesis.dll • Hemorrhage.dll • Pan_Morphometry.dll • Cellularity assessment.dll • Necrosis.dll • Infarction.dll • Fibrosis.dll • Mitoses.dll • Micrometastasis.dll • Adenomyosis.dll Automated Toxicology Screening System

  23. Acknowledgement Development team at Optra Systems, India

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