Large-scale Fluid Structure Interaction Modeling of the Human Brain

1. Computer Simulation Live patient MRI HYDROCEPHALUS DRUG DELIVERY Catheter Cortex TECHNICAL APPROACH: MOVING GRID CODE Post – Processing Solvers MR Imaging Grid Generation Image Reconstruction Novel Moving Grid Code + FLUENT 3-D model of the ventricular system and half of the subarachnoid space. 3-D model of the solid brain (white and gray matter). Velocity magnitude (m/sec) Large-scale Fluid Structure Interaction Modeling of the Human Brain Laboratory for Product and Process Design, Director A. A. LINNINGER Prime Grand Support: NSF, Susman and Asher Foundation • Prediction of large deformations of the brain parenchyma based on Fluid-Structure Interaction modeling. • Coupling of the brain parenchyma, vascular and ventricular system in the human brain. • The therapeutic approach for hydrocephalus treatment is very brutal (shunting) and many revisions are needed. • Ultimate goal: precise model of human brain dynamics to design treatments without in vivo test. • Data from Magnetic Resonance Imaging. • Use of MRI reconstruction tools for generation of 3D patient specific brain geometry. • Introduction of the geometry to Finite Volumes or Finite Elements advanced solvers. • Post processing of the obtained results. • 3D geometric reconstruction of patient-specific brain dimensions based on MRI data • 3D patient-specific dynamic analysis of CSF flow in the human brain • Optimal Drug Delivery to the Human Brain. • Feedback control systems to better treat Hydrocephalus.