1 / 10

Design Project: Degenerative Disc Disease

Design Project: Degenerative Disc Disease. By: Nicholas Mirsky. Background Information. Humans are prone to spinal issues Americans spend 50 billion dollars a year on pain medications. Overlook extremely important muscles in the back when working out.

elysia
Download Presentation

Design Project: Degenerative Disc Disease

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Design Project: Degenerative Disc Disease By: Nicholas Mirsky

  2. Background Information • Humans are prone to spinal issues • Americans spend 50 billion dollars a year on pain medications. • Overlook extremely important muscles in the back when working out. • DDD, when vertebrae degrades over time causing serious issues.

  3. Current Treatment • Physical Therapy • Pain Medication (temp.) • Discectomy Surgery • Lower back strength training.

  4. How it Works Annulus Fibrosus Nucleus Pulposus Inner, soft, jelly like nucleus of the disc. Used as a shock absorber for the back. Prone to inflammation and dehydration as degradation occurs. Contains Aggecan, Fibrillar collagens and water. (main components.) • Firm, stabilizing layer • Acts as the dough in a jelly doughnut. • Hold the nucleus in place. • Grows larger and harder as degradation occurs. • Concentric sheets of collagen fibers.

  5. How it Works (cont.)

  6. DESIGN • Goal: keep disc hydrated over time, preventing the degradation of the disc and to allow for continual shock absorption. • Creation of Aggrecan, a necessary component lost over time, as the collagen increases. • Injected directly as an E. Coli bacterium. • Gene used known as the ACAN Gene.

  7. 1. Outside Inducer: Fibrillar Collagen 2. Receptor: Integrin α11β1 3. Operon (Below) 4. Protein channel 5. Secretion of newly created Protein. 6. Happy hydrated disc

  8. Operon

  9. Protein Channel/ Protein Excretion

  10. Potential Issues/ Unresolved Aspects • Require invention of another Bacterium that would break down Collagen over time in miniscule amounts. • Must add water or water substitute for continuous hydration. • E. Coli may not survive well in area of spine, very little known bacteria there.

More Related