Attention - Class of 2016

1. Attention - Class of 2016 SGD- cytoskeleton and cell junctions 12-12-11, 8.00 am • Please read these topics from ‘Human Physiology- From Cells to System’ by LauraleeSheerwood Latest Edition • You may also consult ‘Textbook of Medical Physiology’ by Guyton & Hall Latest Edition. Focus on: • 1. In Cytoskeleton • Role of microtubules in maintenance of cell shape and complex cell movements • Role of microfilaments in cellular contractile systems and as mechanical stiffeners • Role of intermediate filaments in mechanical stress • How the cytoskeleton links together parts of the cell • 2. In Cell to Cell adhesions • Role of extracellular matrix in cell adhesion • Specialized cell junctions: Desmosomes, Tight junctions, Gap Junctions

2. Attention - Class of 2016 • LGD- Structure and varieties of epithelia 13-12-11, 8.00 am • You should know the following facts of epithelium: • General features of epithelial tissue • Functions of epithelium • Classification of epithelia • Morphology, location and functions of various types of covering/lining epithelia • Features and location of specialized types of epithelia • Modifications of apical domain of epithelial cells • Composition and functions of basal lamina and basement membrane • Classification of glands and their location • Different modes of glandular secretion • Features of serous, mucous and myoepithelial cells

3. Attention - Class of 2016 • SGD- DNA replication 14-12-11, 8.00 am • Consult “Lippincott’s Illustrated Reviews” • 5th Edition • Chapter 29, pages 399-410 • Focus on: • the process of DNA replication (the enzymes involved and the activities taking place at the replication forks) • the role of telomeres in aging and cancer • Please refer to the study guide pages 21-22 for further guidance • (You must be familiar with the structure of DNA to understand DNA replication)

4. Attention - Class of 2016 • SGD- Gene transcription in Prokaryotes and Eukaryotes 14-12-11, 1.30 pm • Consult “Lippincott’s Illustrated Reviews” • Fifth Edition • Chapter 30 pages 417-424 • Focus on: • the major types of cellular RNA and their functions • the major steps of gene transcription (initiation, elongation and termination) in prokaryotes and eukaryotes • the major differences between prokaryotic and eukaryotic gene transcription • Please refer to the study guide pages 25 for further guidance

5. Attention - Class of 2016 • SGD- Protein synthesis 15-12-11, 1.30 pm • Consult “Lippincott’s Illustrated Reviews” • Fifth Edition • Chapter 31, pages 431- 445 • Focus on: • how the nucleotide sequence is translated into the amino acid sequence of a protein • the components required for protein synthesis • initiation, elongation and termination of protein synthesis • how differences in prokaryotic and eukaryotic protein synthesis have been exploited to produce various antibiotics • Post-translational modification of proteins

6. Attention - Class of 2016 • SGD- Regulation of gene expression in eukaryotes 16-12-11, 10.30 am • Consult “Lippincott’s Illustrated Reviews” • Fifth Edition • Chapter 32, pages 454- 461 • Focus on regulation of eukaryotic gene expression through: • trans- and cis- acting molecules • intracellular and cell surface receptors • alternative splicing • mRNA editing • mRNA stability in iron metabolism (we’ll do RNA interference in therapeutics) • translation of mRNA • modifications to DNA